Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | CXCR4 | P61073 | 4/20 | 0.35 |
| ▸ | CCR3 | P51677 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709237 | 0.80 | SCN9A (0.58) | SCN9ANAMPT | |
| SCHEMBL1709243 | 0.77 | SCN9A (0.52) | SCN9AKDM4EMEN1KMT2AMAPT | |
| SCHEMBL10071959 | 0.76 | CCR3 (0.51) | SCN9AALDH1A1MEN1KMT2AGAA | |
| SCHEMBL1709240 | 0.71 | SCN9A (0.60) | SCN9AKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL1709217 | 0.71 | SCN9A (0.48) | SCN9AALDH1A1KMT2AKCNH2P2RX7 | |
| SCHEMBL1709251 | 0.71 | SCN9A (0.54) | SCN9AKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL10072038 | 0.68 | SCN9A (0.53) | SCN9AALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL1966295 | 0.68 | MEN1 (0.70) | MEN1KMT2ATAAR1CXCR4TP53 | |
| SCHEMBL1709241 | 0.67 | SCN9A (0.54) | SCN9AKDM4EALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL10834316 | 0.67 | TAAR1 (0.69) | MEN1KMT2ATAAR1KCNH2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |