SCHEMBL1709240

SCHEMBL1709240

C[C@H](CNCC1CC12CCN(c1ccccc1)CC2)c1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 5/20 0.60
KDM4E B2RXH2 1/20 0.46
ALDH1A1 P00352 1/20 0.46
GFER P55789 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
TAAR1 Q96RJ0 1/20 0.37
AOC3 Q16853 1/20 0.37
ATM Q13315 1/20 0.36
MCOLN2 Q8IZK6 1/20 0.36
BCDIN3D Q7Z5W3 2/20 0.35
SIGMAR1 Q99720 2/20 0.35
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
CYP3A4 P08684 1/20 0.34
MAPK1 P28482 1/20 0.34
CYP2C19 P33261 1/20 0.34
CCR3 P51677 1/20 0.34
USP2 O75604 1/20 0.34
CYP2D6 P10635 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1709243 0.77 SCN9A (0.52) SCN9AKDM4EMEN1KMT2ACYP3A4
SCHEMBL1709238 0.75 SCN9A (0.59) SCN9AALDH1A1ATMSIGMAR1KMT2A
SCHEMBL1709236 0.75 SCN9A (1.00) SCN9AKDM4EALDH1A1GFERL3MBTL1
SCHEMBL1709241 0.74 SCN9A (0.54) SCN9AKDM4EALDH1A1GFERL3MBTL1
SCHEMBL1709251 0.73 SCN9A (0.54) SCN9AKDM4EALDH1A1GFERMEN1
SCHEMBL1709217 0.73 SCN9A (0.48) SCN9AALDH1A1KMT2A
SCHEMBL1709252 0.73 SCN9A (0.56) SCN9ASIGMAR1MEN1KMT2A
SCHEMBL10072038 0.72 SCN9A (0.53) SCN9AALDH1A1MEN1KMT2ACYP3A4
SCHEMBL10071960 0.71 SCN9A (0.49) SCN9AKDM4EALDH1A1TAAR1MEN1
SCHEMBL10071959 0.71 CCR3 (0.51) SCN9AALDH1A1ATMMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012047703-A2 CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS SCHERING CORPORATION (US) 2012-04-12 WO disclosed