Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.45 |
| ▸ | DPP4 | P27487 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 3/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1286796 | 0.76 | USP2 (0.49) | SCN9ASIGMAR1CHRNA7USP2CYP2D6 | |
| SCHEMBL1709252 | 0.75 | SCN9A (0.56) | SCN9ASIGMAR1DRD2CHRNA7DPP4 | |
| SCHEMBL1709240 | 0.74 | SCN9A (0.60) | SCN9ASIGMAR1USP2CYP2D6ALDH1A1 | |
| SCHEMBL10072038 | 0.74 | SCN9A (0.53) | SCN9ACHRNA7USP2CYP2D6CYP2C9 | |
| SCHEMBL1709243 | 0.73 | SCN9A (0.52) | SCN9AUSP2CYP2D6KDM4ECYP3A4 | |
| SCHEMBL1709249 | 0.73 | DRD4 (0.60) | SCN9ASIGMAR1DRD2HTR7ALDH1A1 | |
| SCHEMBL15113487 | 0.72 | CHRM2 (0.30) | — | |
| SCHEMBL1709238 | 0.72 | SCN9A (0.59) | SCN9ASIGMAR1HTR7ALDH1A1NPY1R | |
| SCHEMBL1709236 | 0.71 | SCN9A (1.00) | SCN9ASIGMAR1DRD2USP2CYP2D6 | |
| SCHEMBL1709210 | 0.71 | HTR1A (0.62) | SCN9ASIGMAR1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |