Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709243 | 0.88 | SCN9A (0.52) | SCN9ALMNAKMT2AHTR2AHTR2C | |
| SCHEMBL1709251 | 0.84 | SCN9A (0.54) | SCN9AFFAR4KCNH2ALDH1A1KMT2A | |
| SCHEMBL1709240 | 0.73 | SCN9A (0.60) | SCN9AALDH1A1KMT2A | |
| SCHEMBL1709237 | 0.71 | SCN9A (0.58) | SCN9AHTR2A | |
| SCHEMBL10071960 | 0.71 | SCN9A (0.49) | SCN9AP2RX7KCNH2ALDH1A1KMT2A | |
| SCHEMBL10072038 | 0.70 | SCN9A (0.53) | SCN9ALMNAALDH1A1TSHRKMT2A | |
| SCHEMBL1709241 | 0.69 | SCN9A (0.54) | SCN9AALOX15ALDH1A1 | |
| SCHEMBL10071959 | 0.69 | CCR3 (0.51) | SCN9AALDH1A1KMT2A | |
| SCHEMBL5013644 | 0.67 | MEN1 (0.47) | NPC1RAB9AKMT2A | |
| SCHEMBL1709238 | 0.66 | SCN9A (0.59) | SCN9ALMNARAB9AALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |