Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | FNTA | P49354 | 11/20 | 0.41 |
| ▸ | FNTB | P49356 | 11/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1077676 | 0.82 | ADORA3 (0.48) | ADORA3KMT2AMEN1NPSR1MAPT | |
| SCHEMBL1006034 | 0.78 | MAPT (0.61) | ADORA3KMT2AMEN1NPSR1MAPT | |
| SCHEMBL9371698 | 0.77 | ADORA3 (0.51) | ADORA3KMT2AMEN1NPSR1MAPT | |
| SCHEMBL6967137 | 0.75 | ADORA3 (0.47) | ADORA3KMT2AMEN1NPSR1L3MBTL1 | |
| SCHEMBL6976448 | 0.73 | MAPT (0.54) | ADORA3KMT2AMEN1NPSR1MAPT | |
| SCHEMBL622911 | 0.72 | KDM4E (0.49) | ADORA3KMT2AMEN1NPSR1L3MBTL1 | |
| SCHEMBL6970961 | 0.71 | MAPT (0.53) | ADORA3KMT2AMEN1NPSR1MAPT | |
| SCHEMBL623739 | 0.71 | L3MBTL1 (0.53) | ADORA3KMT2AMEN1NPSR1L3MBTL1 | |
| SCHEMBL6972054 | 0.69 | ALDH1A1 (0.52) | ADORA3KMT2AMEN1NPSR1MAPT | |
| SCHEMBL8281789 | 0.69 | LMNA (0.55) | ADORA3KMT2AMEN1NPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110118236-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-05-19 | — | — | US | disclosed |
| EP-2269990-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2011-01-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118236-A1 | HETEROCYCLIC COMPOUND | GRIN1, GRM1, GRIK1 | ADORA3 135/4885KMT2A 1139/4885MEN1 1454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.