SCHEMBL10075765

SCHEMBL10075765

CC(=O)O/N=C(\C)C(=O)c1ccc(Sc2ccc(C(=O)O)cc2Cl)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.38
KDM4E B2RXH2 4/20 0.37
L3MBTL1 Q9Y468 4/20 0.37
ALDH1A1 P00352 4/20 0.37
HPGD P15428 4/20 0.37
MAPT P10636 3/20 0.37
LMNA P02545 3/20 0.37
NPSR1 Q6W5P4 1/20 0.37
KMT2A Q03164 2/20 0.36
PDE7A Q13946 2/20 0.35
RXRA P19793 1/20 0.34
RXRB P28702 1/20 0.34
RXRG P48443 1/20 0.34
RAB9A P51151 2/20 0.34
GAA P10253 1/20 0.34
ITGAL P20701 1/20 0.34
EGLN1 Q9GZT9 1/20 0.33
NPC1 O15118 1/20 0.33
MRGPRX4 Q96LA9 1/20 0.33
ALOX15 P16050 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10075729 0.87 KDM4E (0.38) TSHRKDM4EL3MBTL1ALDH1A1HPGD
SCHEMBL10075708 0.83 HPGD (0.44) TSHRKDM4EL3MBTL1ALDH1A1HPGD
SCHEMBL20709742 0.81 LMNA (0.34) KDM4EL3MBTL1ALDH1A1HPGDMAPT
SCHEMBL20935148 0.80 L3MBTL1 (0.50) KDM4EL3MBTL1ALDH1A1HPGDMAPT
SCHEMBL19795435 0.78 HPGD (0.56) L3MBTL1ALDH1A1HPGDMAPTLMNA
SCHEMBL16019156 0.78 HPGD (0.56) L3MBTL1ALDH1A1HPGDMAPTLMNA
SCHEMBL19169426 0.76 MAPT (0.46) L3MBTL1ALDH1A1MAPTLMNAKMT2A
SCHEMBL24489413 0.75 L3MBTL1 (0.44) KDM4EL3MBTL1ALDH1A1HPGDMAPT
SCHEMBL19795439 0.75 L3MBTL1 (0.57) KDM4EL3MBTL1ALDH1A1HPGDMAPT
SCHEMBL10075752 0.75 LMNA (0.44) KDM4EL3MBTL1ALDH1A1HPGDMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2586827-B1 CURABLE RESIN COMPOSITION ADEKA CORP (JP) 2017-12-27 EP disclosed
US-8735511-B2 Curing resin composition ADEKA CORPORATION (JP) 2014-05-27 US disclosed
US-8735511-B2 Curing resin composition ADEKA CORPORATION (JP) 2014-05-27 US disclosed
EP-2586827-A1 CURABLE RESIN COMPOSITION Adeka Corporation (JP) 2013-05-01 EP disclosed
US-20120115972-A1 CURING RESIN COMPOSITION ADEKA CORPORATION (JP) 2012-05-10 US disclosed
US-20120115972-A1 CURING RESIN COMPOSITION ADEKA CORPORATION (JP) 2012-05-10 US disclosed
US-8148045-B2 Oxime ester compound and photopolymerization initiator containing the same ADEKA CORPORATION (JP) 2012-04-03 US disclosed
US-8148045-B2 Oxime ester compound and photopolymerization initiator containing the same ADEKA CORPORATION (JP) 2012-04-03 US disclosed
EP-2327689-B1 Oxime ester compound and photopolymerization initiator containing the same ADEKA CORP (JP) 2012-02-29 EP disclosed
US-20110129778-A1 OXIME ESTER COMPOUND AND PHOTOPOLYMERIZATION INITIATOR CONTAINING THE SAME ADEKA CORPORATION (JP) 2011-06-02 US disclosed
US-20110129778-A1 OXIME ESTER COMPOUND AND PHOTOPOLYMERIZATION INITIATOR CONTAINING THE SAME ADEKA CORPORATION (JP) 2011-06-02 US disclosed
EP-2327689-A1 Oxime ester compound and photopolymerization initiator containing the same Adeka Corporation (JP) 2011-06-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110129778-A1 OXIME ESTER COMPOUND AND PHOTOPOLYMERIZATION INITIATOR CONTAINING THE SAME OXER1, OR10J3, CDK11B TSHR 1146/4885KDM4E 1122/4885L3MBTL1 1628/4885
US-20120115972-A1 CURING RESIN COMPOSITION LTA, LOXL1, PLOD2 TSHR 4062/4885KDM4E 15/4885L3MBTL1 228/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.