SCHEMBL1008539

SCHEMBL1008539

c1ccc2cc(Nc3cccc4cccnc34)ccc2c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.59
KMT2A Q03164 4/20 0.59
GLO1 Q04760 4/20 0.59
TDP1 Q9NUW8 3/20 0.59
GRM4 Q14833 1/20 0.56
HDAC6 Q9UBN7 1/20 0.56
MAPT P10636 4/20 0.54
LMNA P02545 2/20 0.54
SLC40A1 Q9NP59 5/20 0.49
SMN1; SMN2 Q16637 3/20 0.49
CYP3A4 P08684 3/20 0.49
ALDH1A1 P00352 1/20 0.49
HPGD P15428 1/20 0.49
HSD17B10 Q99714 1/20 0.49
NPC1 O15118 1/20 0.48
POLB P06746 1/20 0.48
RAB9A P51151 1/20 0.48
BLM P54132 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
ALOX15 P16050 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL379439 0.86 GRM4 (0.57) MEN1KMT2AGLO1TDP1GRM4
SCHEMBL341142 0.83 SLC40A1 (0.62) MEN1KMT2AGLO1TDP1HDAC6
SCHEMBL13337941 0.81 MEN1 (0.56) MEN1KMT2AGLO1TDP1HDAC6
SCHEMBL379216 0.80 GLO1 (0.59) MEN1KMT2AGLO1TDP1HDAC6
SCHEMBL28421763 0.79 GRM4 (0.55) MEN1KMT2AGLO1TDP1GRM4
SCHEMBL24522570 0.79 MAPT (0.67) MEN1KMT2AGLO1TDP1GRM4
SCHEMBL9702768 0.79 HDAC6 (0.65) MEN1KMT2AGLO1TDP1HDAC6
SCHEMBL22926774 0.79 HDAC6 (0.61) MEN1KMT2AGLO1TDP1HDAC6
SCHEMBL9850583 0.79 MEN1 (0.51) MEN1KMT2AGLO1TDP1GRM4
SCHEMBL29688279 0.78 ALDH1A1 (0.68) MEN1KMT2AMAPTLMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1801189-B1 Synergistic lubricating oil composition containing a mixture of a benzo[b]perhydroheterocyclic arylamine and a diarylamine CHEVRON ORONITE CO (US) 2012-11-07 EP disclosed
US-8003583-B2 Benzo[b]perhydroheterocyclic arylamines and lubricating oil compositions CHEVRON ORONITE COMPANY LLC (US) 2011-08-23 US disclosed
US-8003583-B2 Benzo[b]perhydroheterocyclic arylamines and lubricating oil compositions CHEVRON ORONITE COMPANY LLC (US) 2011-08-23 US disclosed
US-8003583-B2 Benzo[b]perhydroheterocyclic arylamines and lubricating oil compositions CHEVRON ORONITE COMPANY LLC (US) 2011-08-23 US disclosed
EP-1801104-B1 Benzo[b]perhydroheterocyclic arylamines and lubricating oil compositions CHEVRON ORONITE CO (US) 2011-01-05 EP disclosed
EP-1801104-B1 Benzo[b]perhydroheterocyclic arylamines and lubricating oil compositions CHEVRON ORONITE CO (US) 2011-01-05 EP disclosed
US-7501386-B2 Lubricants for automotive and truck crankcase lubricants; as well as transmission lubricants, gear lubricants, hydraulic fluids, compressor oils, diesel and marine lubricants; superior oxidation inhibition; Phenyl-(1,2,3,4-tetrahydro-quinolin-6-yl)-amine, diphenylamine CHEVRON ORONITE COMPANY, LLC (US) 2009-03-10 US disclosed
EP-1801104-A2 Benzo[b]perhydroheterocyclic arylamines and lubricating oil compositions Chevron Oronite Company LLC (US) 2007-06-27 EP disclosed
EP-1801104-A2 Benzo[b]perhydroheterocyclic arylamines and lubricating oil compositions Chevron Oronite Company LLC (US) 2007-06-27 EP disclosed
EP-1801189-A2 Synergistic lubricating oil composition containing a mixture of a benzo[b]perhydroheterocyclic arylamine and a diarylamine Chevron Oronite Company LLC (US) 2007-06-27 EP disclosed
US-20070142243-A1 Synergistic lubricating oil composition containing a mixture of a benzo[b]perhydroheterocyclic arylamine and a diarylamine CHEVRON ORONITE COMPANY LLC 2007-06-21 US disclosed
US-20070142246-A1 Benzo[b]perhydroheterocyclic arylamines and lubricating oil compositions CHEVRON ORONITE COMPANY LLC 2007-06-21 US disclosed
US-20070142246-A1 Benzo[b]perhydroheterocyclic arylamines and lubricating oil compositions CHEVRON ORONITE COMPANY LLC 2007-06-21 US disclosed
US-20070142246-A1 Benzo[b]perhydroheterocyclic arylamines and lubricating oil compositions CHEVRON ORONITE COMPANY LLC 2007-06-21 US disclosed
US-4152324-A FOR LACQUERS, PAINTS, AND PRINTING INKS CIBA-GEIGY CORPORATION (US) 1979-05-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070142246-A1 Benzo[b]perhydroheterocyclic arylamines and lubricating oil compositions AHR, ARNT, HRH2 MEN1 4728/4885KMT2A 2405/4885GLO1 1660/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.