Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | PFKFB2 | O60825 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | PFKFB1 | P16118 | 1/20 | 0.37 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.37 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.37 |
| ▸ | AS3MT | Q9HBK9 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.36 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10097378 | 0.93 | ALDH1A1 (0.39) | ALDH1A1PFKFB2NSD2PFKFB1PFKFB3 | |
| SCHEMBL10097444 | 0.91 | HDAC1 (0.40) | ALDH1A1KDRCA12CA1CA2 | |
| SCHEMBL10097408 | 0.91 | ALDH1A1 (0.38) | ALDH1A1PFKFB2NSD2PFKFB1PFKFB3 | |
| SCHEMBL10097553 | 0.91 | MTNR1B (0.40) | MTNR1BKDRLIMK1LIMK2MEN1 | |
| SCHEMBL10097391 | 0.89 | ALDH1A1 (0.39) | ALDH1A1PFKFB2NSD2PFKFB1PFKFB3 | |
| SCHEMBL10249577 | 0.89 | ALDH1A1 (0.42) | ALDH1A1PFKFB2NSD2PFKFB1PFKFB3 | |
| SCHEMBL10097452 | 0.88 | ALDH1A1 (0.41) | ALDH1A1PFKFB2NSD2PFKFB1PFKFB3 | |
| SCHEMBL10249891 | 0.87 | ALDH1A1 (0.41) | ALDH1A1MTNR1BPFKFB2NSD2PFKFB1 | |
| SCHEMBL10096245 | 0.86 | PFKFB2 (0.43) | ALDH1A1MTNR1BPFKFB2NSD2PFKFB1 | |
| SCHEMBL10250941 | 0.86 | SMN1; SMN2 (0.41) | ALDH1A1PFKFB2NSD2PFKFB1PFKFB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120027721-A1 | HCV Inhibitor and Therapeutic Agent Combinations | PTC THERAPEUTICS, INC. (US) | 2012-02-02 | — | — | US | disclosed |
| US-7868037-B2 | Methods for treating hepatitis C | PTC THERAPEUTICS, INC. (US) | 2011-01-11 | — | — | US | disclosed |
| WO-2010118009-A1 | HCV INHIBITOR AND THERAPEUTIC AGENT COMBINATIONS | PTC THERAPEUTICS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |
| US-7781478-B2 | Methods for treating hepatitis C | PTC THERAPEUTICS, INC. (US) | 2010-08-24 | — | — | US | disclosed |
| US-20070299069-A1 | Methods for treating hepatitis C | PTC THERAPEUTICS, INC. | 2007-12-27 | — | — | US | disclosed |
| WO-2007084435-A2 | METHODS FOR TREATING HEPATITIS C | PTC THERAPEUTICS, INC. (US) | 2007-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299069-A1 | Methods for treating hepatitis C | HAVCR2, EIF2AK2, MAVS | ALDH1A1 1497/4885MTNR1B 2599/4885PFKFB2 4493/4885 |
| US-20120027721-A1 | HCV Inhibitor and Therapeutic Agent Combinations | HAVCR2, SERPINB1, ENPEP | ALDH1A1 1067/4885MTNR1B 827/4885PFKFB2 4202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.