Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.75 |
| ▸ | RAB9A | P51151 | 2/20 | 0.75 |
| ▸ | NPC1 | O15118 | 1/20 | 0.75 |
| ▸ | LMNA | P02545 | 1/20 | 0.75 |
| ▸ | TP53 | P04637 | 1/20 | 0.75 |
| ▸ | MAPT | P10636 | 1/20 | 0.75 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.75 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.75 |
| ▸ | FURIN | P09958 | 1/20 | 0.56 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.54 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.51 |
| ▸ | F2 | P00734 | 2/20 | 0.51 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.51 |
| ▸ | PLAU | P00749 | 1/20 | 0.51 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.51 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.51 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.51 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.51 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.51 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8739981 | 1.00 | GAA (0.75) | GAARAB9ANPC1LMNATP53 | |
| Pentamidine Dao SCHEMBL12355833 | 0.90 | GAA (0.84) | GAARAB9ANPC1LMNATP53 | |
| SCHEMBL14599580 | 0.90 | GAA (0.84) | GAARAB9ANPC1LMNATP53 | |
| SCHEMBL14599647 | 0.90 | GAA (0.84) | GAARAB9ANPC1LMNATP53 | |
| Pentamidine Dao SCHEMBL8653348 | 0.90 | GAA (0.84) | GAARAB9ANPC1LMNATP53 | |
| SCHEMBL14599579 | 0.90 | GAA (0.84) | GAARAB9ANPC1LMNATP53 | |
| SCHEMBL14599648 | 0.90 | GAA (0.84) | GAARAB9ANPC1LMNATP53 | |
| Pentamidine Dao SCHEMBL12348101 | 0.90 | GAA (0.84) | GAARAB9ANPC1LMNATP53 | |
| SCHEMBL8739980 | 0.86 | PRMT1 (0.73) | GAARAB9ANPC1LMNATP53 | |
| SCHEMBL2368560 | 0.86 | GAA (1.00) | GAARAB9ANPC1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8207345-B2 | Antitumor agents; use in combination with other drugs such as pentamidine | MERCK PATENT GMBH (DE) | 2012-06-26 | — | — | US | disclosed |
| US-8110583-B2 | treatment of tumors; 1,5-bis(4'-(N-hydroxyamidino)phenoxy)pentane; maintain cells in the G2/M cell cycle | MERCK PATENT GMBH (DE) | 2012-02-07 | — | — | US | disclosed |
| US-7915416-B2 | Tetrahydroquinolines | MERCK PATENT GMBH (DE) | 2011-03-29 | — | — | US | disclosed |
| US-7875614-B2 | compounds for treatment of tumors | MERCK PATENT GMBH (DE) | 2011-01-25 | — | — | US | disclosed |
| US-7868172-B2 | 2-(hetero)-aryl substituted tetrahydroquinoline derivatives | MERCK PATENT GMBH (DE) | 2011-01-11 | — | — | US | disclosed |
| US-20100120818-A1 | SUBSTITUTED TETRAHYDROPYRROLOQUINOLINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-05-13 | — | — | US | disclosed |
| US-20100076012-A1 | TETRAHYDROQUINOLINE DERIVATIVES AND THE USE THEREOF FOR THE TREATMENT OF CANCER | MERCK PATENT GMBH (DE) | 2010-03-25 | — | — | US | disclosed |
| US-20090118267-A1 | INDANES | MERCK PATENT GMBH (DE) | 2009-05-07 | — | — | US | disclosed |
| US-20090030028-A1 | Tetrahydroquinolines | MERCK PATENT GMBH (DE) | 2009-01-29 | — | — | US | disclosed |
| US-20080234299-A1 | Quinazolinones | MERCK PATENT GMBH (DE) | 2008-09-25 | — | — | US | disclosed |
| US-20080221118-A1 | treatment of tumors; 1,5-bis(4'-(N-hydroxyamidino)phenoxy)pentane; maintain cells in the G2/M cell cycle | MERCK PATENT GMBH (DE) | 2008-09-11 | — | — | US | disclosed |
| US-20080200451-A1 | Tetrahydroquinolines for Use as Modulators of the Mitotic Motor Protein Eg5 | MERCK PATENT GMBH (DE) | 2008-08-21 | — | — | US | disclosed |
| US-20080194569-A1 | Phthalazinones | MERCK PATENT GMBH (DE) | 2008-08-14 | — | — | US | disclosed |
| US-20070219246-A1 | Dihydrobenzothiophenes | MERCK PATENT GMBH (DE) | 2007-09-20 | — | — | US | disclosed |
| US-20070203167-A1 | 2-(Hetero)-aryl substituted tetrahydrochinoline | MERCK PATENT GMBH (DE) | 2007-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194569-A1 | Phthalazinones | RB1, H1-3, H1-2 | GAA 3424/4885RAB9A 1248/4885NPC1 1983/4885 |
| US-20080200451-A1 | Tetrahydroquinolines for Use as Modulators of the Mitotic Motor Protein Eg5 | KIF5A, KIF5C, KIF5B | GAA 2068/4885RAB9A 261/4885NPC1 3500/4885 |
| US-20090118267-A1 | INDANES | IDH3A, CYP1A1, CCNT1 | GAA 4518/4885RAB9A 2155/4885NPC1 1432/4885 |
| US-20080234299-A1 | Quinazolinones | H1-3, NDUFS3, CCNT1 | GAA 3655/4885RAB9A 229/4885NPC1 2274/4885 |
| US-20100076012-A1 | TETRAHYDROQUINOLINE DERIVATIVES AND THE USE THEREOF FOR THE TREATMENT OF CANCER | RECQL, NDUFS3, SDHA | GAA 4326/4885RAB9A 1239/4885NPC1 2678/4885 |
| US-20090030028-A1 | Tetrahydroquinolines | RECQL, QTRT1, NRAS | GAA 3810/4885RAB9A 743/4885NPC1 1965/4885 |
| US-20070203167-A1 | 2-(Hetero)-aryl substituted tetrahydrochinoline | NCOR1, CCNT2, NCOR2 | GAA 4282/4885RAB9A 1719/4885NPC1 1194/4885 |
| US-20070219246-A1 | Dihydrobenzothiophenes | CCNT1, CCNT2, TPT1 | GAA 3665/4885RAB9A 2614/4885NPC1 3392/4885 |
| US-20100120818-A1 | SUBSTITUTED TETRAHYDROPYRROLOQUINOLINES | TPD52L2, CCNT1, IDH2 | GAA 4657/4885RAB9A 1796/4885NPC1 2665/4885 |
| US-20080221118-A1 | treatment of tumors; 1,5-bis(4'-(N-hydroxyamidino)phenoxy)pentane; maintain cells in the G2/M cell cycle | CCNE1, CCNA1, CCNT1 | GAA 4608/4885RAB9A 3850/4885NPC1 3948/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.