Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3486 | 0.91 | TRPM8 (0.42) | ALDH1A1MEN1KMT2AKDM4ENPC1 | |
| SCHEMBL10451 | 0.90 | PPARG (0.39) | ALDH1A1MEN1KMT2AKDM4ENPC1 | |
| SCHEMBL10539 | 0.88 | SLC7A5 (0.52) | MEN1KMT2AKDM4ENPC1RAB9A | |
| SCHEMBL7763989 | 0.82 | ALDH1A1 (0.33) | ALDH1A1MEN1KMT2AKDM4ENPC1 | |
| SCHEMBL3994 | 0.81 | L3MBTL1 (0.41) | ALDH1A1KMT2ANPC1RAB9AL3MBTL1 | |
| SCHEMBL1535377 | 0.78 | SLC6A2 (0.56) | ALDH1A1MEN1KMT2AKDM4ENPC1 | |
| SCHEMBL3312531 | 0.78 | SLC6A2 (0.56) | ALDH1A1MEN1KMT2AKDM4ENPC1 | |
| SCHEMBL2741 | 0.78 | SLC6A2 (0.56) | ALDH1A1MEN1KMT2AKDM4ENPC1 | |
| SCHEMBL3568 | 0.77 | SLC6A4 (0.45) | ALDH1A1MEN1KMT2AKDM4ENPC1 | |
| SCHEMBL3700 | 0.76 | SLC6A4 (0.44) | ALDH1A1MEN1KMT2AKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023269-A | 3-aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1991-06-11 | — | — | US | disclosed |
| EP-0273658-B1 | 3-ARYLOXY-3-SUBSTITUTED PROPANAMINES | ELI LILLY AND COMPANY (US) | 1990-10-31 | — | — | EP | disclosed |
| US-4956388-A | ANTIDEPRESSANTS, ANTIANXIETY, TREATMENT OF OBESITY, ADDICTION TO SMOKING AND ALCOHOL | ELI LILLY AND COMPANY (US) | 1990-09-11 | — | — | US | disclosed |
| EP-0273658-A1 | 3-Aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1988-07-06 | — | — | EP | disclosed |