SCHEMBL10102845

SCHEMBL10102845

C=CC(=O)Oc1ccc(/C=C\c2ccc(N(c3ccccc3)c3ccc(C=C(c4ccccc4)c4ccccc4)cc3)cc2)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.40
TRPM8 Q7Z2W7 3/20 0.40
CYP2D6 P10635 1/20 0.38
THRB P10828 2/20 0.38
PTGS2 P35354 1/20 0.38
MAPT P10636 4/20 0.37
KDM4E B2RXH2 2/20 0.37
ALDH1A1 P00352 2/20 0.37
HPGD P15428 2/20 0.37
MEN1 O00255 1/20 0.37
HSP90AA1 P07900 1/20 0.37
RAD51 Q06609 1/20 0.37
RAB9A P51151 2/20 0.37
NPC1 O15118 1/20 0.37
CTDSP1 Q9GZU7 1/20 0.37
BCHE P06276 1/20 0.36
CYP3A4 P08684 1/20 0.36
NFKB1 P19838 1/20 0.36
NFKB2 Q00653 1/20 0.36
RELA Q04206 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13818605 1.00 KMT2A (0.40) KMT2ATRPM8CYP2D6THRBPTGS2
SCHEMBL9915682 0.96 THRB (0.40) KMT2ATRPM8CYP2D6THRBPTGS2
SCHEMBL13777756 0.95 CYP2D6 (0.42) KMT2ACYP2D6THRBPTGS2MAPT
SCHEMBL9915754 0.95 CYP2D6 (0.42) KMT2ACYP2D6THRBPTGS2MAPT
SCHEMBL2609801 0.95 CYP2D6 (0.42) KMT2ACYP2D6THRBPTGS2MAPT
SCHEMBL9915809 0.95 PTGS2 (0.41) KMT2ACYP2D6THRBPTGS2MAPT
SCHEMBL11987116 0.94 ALDH1A1 (0.42) KMT2ATRPM8CYP2D6THRBPTGS2
SCHEMBL13818602 0.90 KMT2A (0.48) KMT2ATRPM8THRBMAPTKDM4E
SCHEMBL2609797 0.90 KMT2A (0.48) KMT2ATRPM8THRBMAPTKDM4E
SCHEMBL13213541 0.90 KMT2A (0.48) KMT2ATRPM8THRBMAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8148038-B2 Image bearing member, process cartridge, image forming apparatus and method of forming image bearing member RICOH COMPANY, LTD. (JP) 2012-04-03 US disclosed
US-7718335-B2 Image bearing member, and image forming apparatus and process cartridge using the same RICOH COMPANY LIMITED (JP) 2010-05-18 US disclosed
US-7718335-B2 Image bearing member, and image forming apparatus and process cartridge using the same RICOH COMPANY LIMITED (JP) 2010-05-18 US disclosed
US-20070196750-A1 IMAGE BEARING MEMBER, AND IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE USING THE SAME RICOH COMPANY, LIMITED. (JP) 2007-08-23 US disclosed
US-20070196750-A1 IMAGE BEARING MEMBER, AND IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE USING THE SAME RICOH COMPANY, LIMITED. (JP) 2007-08-23 US disclosed
US-20070031746-A1 Electrophotographic photoconductor, process cartridge, and image forming method RICOH COMPANY, LTD. (JP) 2007-02-08 US disclosed
US-20070031746-A1 Electrophotographic photoconductor, process cartridge, and image forming method RICOH COMPANY, LTD. (JP) 2007-02-08 US disclosed