SCHEMBL1010735

SCHEMBL1010735

COC(=O)C(C)(C)C(=O)O

nearest known ligand 0.56

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 1/20 0.56
TSHR P16473 3/20 0.40
ELANE P08246 2/20 0.40
ALDH1A1 P00352 2/20 0.40
KCNN4 O15554 1/20 0.39
CYP2D6 P10635 1/20 0.38
CYP2C19 P33261 1/20 0.38
HIF1A Q16665 1/20 0.38
SRC P12931 1/20 0.35
MAPT P10636 1/20 0.31
HCAR2 Q8TDS4 2/20 0.31
KEAP1 Q14145 1/20 0.30
NFE2L2 Q16236 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28803702 0.97 DGAT1 (0.54) DGAT1TSHRELANEALDH1A1KCNN4
Hydrochloric Acid SCHEMBL10829675 0.97 DGAT1 (0.54) DGAT1TSHRELANEALDH1A1KCNN4
SCHEMBL30440750 0.97 DGAT1 (0.54) DGAT1TSHRELANEALDH1A1KCNN4
SCHEMBL808799 0.84 DGAT1 (0.74) DGAT1TSHRELANEALDH1A1KCNN4
SCHEMBL23091415 0.81 DGAT1 (0.70) DGAT1TSHRELANEALDH1A1KCNN4
Ammonia Solution, Strong SCHEMBL7639328 0.81 DGAT1 (0.70) DGAT1TSHRELANEALDH1A1KCNN4
Iodide SCHEMBL10533676 0.81 DGAT1 (0.70) DGAT1TSHRELANEALDH1A1KCNN4
SCHEMBL27905901 0.81 DGAT1 (0.70) DGAT1TSHRELANEALDH1A1KCNN4
SCHEMBL5859056 0.79 DGAT1 (0.59) DGAT1TSHRELANEALDH1A1KCNN4
SCHEMBL9067049 0.79 TSHR (0.42) DGAT1TSHRELANEALDH1A1KCNN4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 164 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114605622-A Aliphatic polyester with malonic acid structure and preparation method and application thereof 苏州瀚海新材料有限公司 2022-06-10 CN claimed
EP-0674233-B1 Recording sheets XEROX CORP (US) 2000-05-24 EP claimed
US-5928765-A Recording sheets XEROX CORPORATION (US) 1999-07-27 US claimed
EP-0674233-A2 Recording sheets XEROX CORPORATION (US) 1995-09-27 EP claimed
US-20250067907-A1 COMPOUNDS AND METHODS FOR TREATING HYPERKALEMIA ARDELYX, INC. (US) 2025-02-27 US disclosed
US-20250064789-A1 KETOAMIDE DERIVATIVES AND PHARMACEUTICAL USES THEREOF WESTVAC BIOPHARMA CO., LTD. (CN) 2025-02-27 US disclosed
EP-4488264-A1 KETO AMIDE DERIVATIVES AND PHARMACEUTICAL USE THEREOF WestVac Biopharma Co., Ltd. (CN) 2025-01-08 EP disclosed
US-12139462-B2 Pyridinone MK2 inhibitors and uses thereof XINTHERA, INC. (US) 2024-11-12 US disclosed
CN-116693447-B Ketone amide derivative and pharmaceutical application thereof 成都威斯克生物医药有限公司 2024-08-13 CN disclosed
EP-4397366-A2 GLYCYRRHETINIC ACID DERIVATIVES FOR TREATING HYPERKALEMIA Ardelyx, Inc. (US) 2024-07-10 EP disclosed
EP-4367099-A1 PYRIDINONE MK2 INHIBITORS AND USES THEREOF Xinthera, Inc. (US) 2024-05-15 EP disclosed
CN-112601735-B Compound, colored resin composition, color filter and display device 东友精细化工有限公司 2024-05-14 CN disclosed
EP-0066884-A2 Oxygen-adsorbing and desorbing agent TAIHO PHARMACEUTICAL CO., LTD. (JP) 1982-12-15 EP disclosed
US-4327189-A USING AN ENDCAPPED ACETAL RESIN HAVING STABILITY AGAINST DEPOLYMERIZATION MONSANTO COMPANY (US) 1982-04-27 US disclosed
EP-0049589-A1 Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines E.R. Squibb & Sons, Inc. (US) 1982-04-14 EP disclosed
US-4311705-A HYPOTENSIVE AGENTS E. R. SQUIBB & SONS, INC. (US) 1982-01-19 US disclosed
US-4303777-A DEFLOCCULATION AGENT MONSANTO COMPANY (US) 1981-12-01 US disclosed
US-4302564-A ADDING AN ELECTRONEGATIVE END GROUP TO AN ACETAL RESIN OF AN ESTER OF GLYOXYLIC ACID MONSANTO COMPANY (US) 1981-11-24 US disclosed
US-4238506-A SECONDARY OR TERTIARY AMIDE-SUBSTITUTED BOEHRINGER MANNHEIM GMBH (DE) 1980-12-09 US disclosed
US-4113871-A HYPOGLYCEMICALLY AND HYPOLIPIDEMICALLY ACTIVE DERIVATIVES OF PHENYL-ALKANE-CARBOXYLIC ACIDS BOEHRINGER MANNHEIM GMBH (DE) 1978-09-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12139462-B2 Pyridinone MK2 inhibitors and uses thereof ENPP2, PLP2, PDXK DGAT1 3136/4885TSHR 3826/4885ELANE 3566/4885
US-20250067907-A1 COMPOUNDS AND METHODS FOR TREATING HYPERKALEMIA REN, NHERF1, KCNJ11 DGAT1 4553/4885TSHR 667/4885ELANE 1892/4885
US-20250064789-A1 KETOAMIDE DERIVATIVES AND PHARMACEUTICAL USES THEREOF ACE2, ACE, PKD2 DGAT1 257/4885TSHR 3558/4885ELANE 4690/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.