Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10116451 | 0.90 | ADRB2 (0.54) | ADRA1ACYP3A4ADRB2ADRA2CADRA2A | |
| SCHEMBL12287039 | 0.90 | ADRB2 (0.54) | ADRA1ACYP3A4ADRB2ADRA2CADRA2A | |
| SCHEMBL10116452 | 0.88 | ALDH1A1 (0.49) | ADRA1ACYP3A4ADRB2ADRA2CADRA2A | |
| SCHEMBL16687896 | 0.79 | ALDH1A1 (0.44) | ADRA1ACYP3A4ADRB2ADRA2CADRA2A | |
| SCHEMBL10116454 | 0.79 | CYP3A4 (0.43) | ADRA1ACYP3A4ADRB2ADRA2CADRA2A | |
| SCHEMBL23339689 | 0.77 | LMNA (0.71) | ADRA1ACYP3A4ADRB2ADRA2CADRA2A | |
| SCHEMBL11526487 | 0.77 | LMNA (0.71) | ADRA1ACYP3A4ADRB2ADRA2CADRA2A | |
| SCHEMBL8904463 | 0.76 | ADRA1A (0.56) | ADRA1ACYP3A4ADRB2ADRA2CADRA2A | |
| SCHEMBL23720612 | 0.76 | HTR2A (0.47) | CYP3A4ADRB2ALDH1A1LMNAHIF1A | |
| Hydrochloric Acid SCHEMBL8905797 | 0.74 | BLM (0.58) | ADRA1ACYP3A4ADRB2ADRA2CADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9023788-B2 | Methods compounds and pharmaceutical compositions for treating anxiety and mood disorders | NEW YORK UNIVERSITY (US) | 2015-05-05 | — | — | US | disclosed |
| US-9023788-B2 | Methods compounds and pharmaceutical compositions for treating anxiety and mood disorders | NEW YORK UNIVERSITY (US) | 2015-05-05 | — | — | US | disclosed |
| WO-2012142388-A2 | METHODS, COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING ANXIETY AND MOOD DISORDERS | NEW YORK UNIVERSITY (US) | 2012-10-18 | — | — | WO | disclosed |
| US-20120010125-A1 | Methods, compounds and pharmaceutical compositions for treating anxiety and mood disorders | STONE ERIC A (US) | 2012-01-12 | — | — | US | disclosed |
| US-20120010125-A1 | Methods, compounds and pharmaceutical compositions for treating anxiety and mood disorders | STONE ERIC A (US) | 2012-01-12 | — | — | US | disclosed |
| WO-2011133212-A1 | METHODS, COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING ANXIETY AND MOOD DISORDERS | NEW YORK UNIVERSITY (US) | 2011-10-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010125-A1 | Methods, compounds and pharmaceutical compositions for treating anxiety and mood disorders | HTR1B, HTR1A, HTR2B | ADRA1A 20/4885CYP3A4 906/4885ADRB2 49/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.