Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.50 |
| ▸ | BLM | P54132 | 5/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.49 |
| ▸ | ELANE | P08246 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | RECQL | P46063 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | APEX1 | P27695 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23339689 | 1.00 | LMNA (0.71) | LMNAHIF1ACYP3A4ALDH1A1ADRB2 | |
| SCHEMBL11264848 | 0.85 | ALDH1A1 (0.71) | LMNAHIF1ACYP3A4ALDH1A1ADRB2 | |
| SCHEMBL23318971 | 0.83 | ALDH1A1 (0.56) | LMNAHIF1ACYP3A4ALDH1A1ADRB2 | |
| Dipivefrin SCHEMBL20673238 | 0.83 | HIF1A (1.00) | LMNAHIF1ACYP3A4ALDH1A1ADRB2 | |
| Dipivefrin SCHEMBL29710905 | 0.83 | HIF1A (1.00) | LMNAHIF1ACYP3A4ALDH1A1ADRB2 | |
| Dipivefrin SCHEMBL24714 | 0.83 | HIF1A (1.00) | LMNAHIF1ACYP3A4ALDH1A1ADRB2 | |
| Dipivefrin SCHEMBL24713 | 0.83 | HIF1A (1.00) | LMNAHIF1ACYP3A4ALDH1A1ADRB2 | |
| Dipivefrin SCHEMBL41351 | 0.82 | ADRB2 (1.00) | LMNAHIF1ACYP3A4ALDH1A1ADRB2 | |
| SCHEMBL11275258 | 0.82 | LMNA (0.78) | LMNAHIF1ACYP3A4ALDH1A1ADRB2 | |
| Dipivefrin SCHEMBL41350 | 0.82 | ADRB2 (1.00) | LMNAHIF1ACYP3A4ALDH1A1ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4145441-A | SYMPATHOMIMETIC AMINES EXHIBITING ANTI-HEMORRHOIDAL ACTIVITY | INTERX RESEARCH CORPORATION (US) | 1979-03-20 | — | — | US | claimed |
| US-4145441-A | SYMPATHOMIMETIC AMINES EXHIBITING ANTI-HEMORRHOIDAL ACTIVITY | INTERX RESEARCH CORPORATION (US) | 1979-03-20 | — | — | US | disclosed |