SCHEMBL10118252

SCHEMBL10118252

Cc1cc(Cl)cc(C(=O)NC(C)C)c1NC(=O)c1cc(C(=O)Nc2ccc(C(F)(F)F)cc2)nn1-c1ncccc1Cl

nearest known ligand 0.58

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 10/20 0.43
NPY5R Q15761 3/20 0.40
KDR P35968 1/20 0.39
TEK Q02763 1/20 0.39
NR3C1 P04150 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10118273 0.94 NPY5R (0.42) TRPV1NPY5RKDR
SCHEMBL10118247 0.93 TRPV1 (0.42) TRPV1NPY5RNR3C1
SCHEMBL10118261 0.92 TRPV1 (0.45) TRPV1NPY5RKDRTEKNR3C1
SCHEMBL672741 0.87 PDE4B (0.36) TRPV1
SCHEMBL10118268 0.85 NPY5R (0.43) TRPV1NPY5RKDR
SCHEMBL12936147 0.85 KMT2A (0.38)
SCHEMBL782483 0.85 MALT1 (0.37)
SCHEMBL782139 0.85 DHODH (0.33) TRPV1NR3C1
SCHEMBL10118246 0.84 TRPV1 (0.44) TRPV1NPY5RKDRNR3C1
SCHEMBL10136612 0.84 ALDH1A1 (0.35) TRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2582688-B1 ANTHRANILIC ACID DIAMIDE DERIVATIVES BAYER IP GMBH (DE) 2015-10-07 EP disclosed
US-8791139-B2 Anthranilic diamide derivatives BAYER CROPSCIENCE AG (DE) 2014-07-29 US disclosed
US-8791139-B2 Anthranilic diamide derivatives BAYER CROPSCIENCE AG (DE) 2014-07-29 US disclosed
US-20120015980-A1 ANTHRANILIC DIAMIDE DERIVATIVES BAYER CROPSCIENCE AG (DE) 2012-01-19 US disclosed
US-20120015980-A1 ANTHRANILIC DIAMIDE DERIVATIVES BAYER CROPSCIENCE AG (DE) 2012-01-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120015980-A1 ANTHRANILIC DIAMIDE DERIVATIVES DDT, QDPR, ANTXR2 TRPV1 2761/4885NPY5R 443/4885KDR 3456/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.