SCHEMBL10136612

SCHEMBL10136612

Cc1cc(Cl)cc(C(=O)NC(C)C)c1NC(=O)c1cc(CNS(=O)(=O)c2ccc(C(F)(F)F)cc2)nn1-c1ncccc1Cl

nearest known ligand 0.52

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.35
HTR6 P50406 1/20 0.35
TP53 P04637 2/20 0.35
MAPT P10636 2/20 0.35
PDK1 Q15118 1/20 0.35
PDK2 Q15119 1/20 0.35
PDK3 Q15120 1/20 0.35
PDK4 Q16654 1/20 0.35
LMNA P02545 2/20 0.34
TRPV1 Q8NER1 1/20 0.33
CCR9 P51686 1/20 0.33
DHODH Q02127 1/20 0.33
CNR1 P21554 1/20 0.33
CYP3A4 P08684 2/20 0.32
UGCG Q16739 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10118322 0.95 ALDH1A1 (0.35) ALDH1A1HTR6TP53MAPTPDK1
SCHEMBL10136626 0.93 POLB (0.37) ALDH1A1HTR6TP53MAPTPDK1
SCHEMBL10136915 0.93 TP53 (0.36) ALDH1A1HTR6TP53MAPTLMNA
SCHEMBL10136248 0.93 LMNA (0.41) ALDH1A1HTR6TP53MAPTPDK1
SCHEMBL10136642 0.92 ALDH1A1 (0.35) ALDH1A1TRPV1DHODHCNR1CYP3A4
SCHEMBL10136314 0.92 HTR6 (0.39) ALDH1A1HTR6TP53LMNA
SCHEMBL10136627 0.92 ALDH1A1 (0.39) ALDH1A1HTR6LMNADHODHCNR1
SCHEMBL10136243 0.91 ALDH1A1 (0.40) ALDH1A1HTR6MAPTLMNADHODH
SCHEMBL10136313 0.89 HTR6 (0.36) ALDH1A1HTR6TP53LMNATRPV1
SCHEMBL10136641 0.89 ALDH1A1 (0.34) ALDH1A1DHODHCNR1CYP3A4UGCG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8791139-B2 Anthranilic diamide derivatives BAYER CROPSCIENCE AG (DE) 2014-07-29 US disclosed
US-20120015980-A1 ANTHRANILIC DIAMIDE DERIVATIVES BAYER CROPSCIENCE AG (DE) 2012-01-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120015980-A1 ANTHRANILIC DIAMIDE DERIVATIVES DDT, QDPR, ANTXR2 ALDH1A1 732/4885HTR6 4439/4885TP53 3049/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.