Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 8/20 | 0.34 |
| ▸ | IDH1 | O75874 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10106316 | 1.00 | HTR3A (0.34) | HTR3AIDH1LMNACYP2C9 | |
| SCHEMBL7809720 | 0.82 | LMNA (0.43) | LMNACYP2C9 | |
| SCHEMBL7809722 | 0.82 | LMNA (0.43) | LMNACYP2C9 | |
| SCHEMBL16082476 | 0.81 | HTR3A (0.34) | HTR3A | |
| SCHEMBL18017 | 0.74 | LMNA (0.38) | LMNACYP2C9 | |
| SCHEMBL16389219 | 0.73 | HTR3A (0.30) | HTR3A | |
| SCHEMBL19388940 | 0.71 | HTR3A (0.32) | HTR3A | |
| SCHEMBL15421001 | 0.68 | CHRM2 (0.57) | LMNA | |
| SCHEMBL22777402 | 0.68 | CHRM2 (0.57) | LMNA | |
| SCHEMBL10120550 | 0.68 | CHRM2 (0.57) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120040975-A1 | BRIDGED BICYCLIC HETEROCYCLE DERIVATIVES AND METHODS OF USE THEREOF | MERCK SHARP & DOHME CORP. | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040975-A1 | BRIDGED BICYCLIC HETEROCYCLE DERIVATIVES AND METHODS OF USE THEREOF | GPR119, BDKRB2, GLP1R | HTR3A 137/4885IDH1 2270/4885LMNA 2033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.