Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | FDPS | P14324 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14654319 | 0.90 | TDP1 (0.47) | LMNAALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL24189141 | 0.88 | FDPS (0.47) | LMNAFDPSALDH1A1MAPTHPGD | |
| SCHEMBL10879566 | 0.88 | TDP1 (0.51) | LMNAFDPSALDH1A1MAPTHPGD | |
| SCHEMBL12280905 | 0.88 | TDP1 (0.46) | LMNAALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL13212088 | 0.87 | HTT (0.41) | LMNAFDPSALDH1A1MAPTHPGD | |
| SCHEMBL10123078 | 0.87 | HTT (0.41) | LMNAFDPSALDH1A1MAPTHPGD | |
| SCHEMBL12281340 | 0.86 | ALDH1A1 (0.39) | LMNAALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL13435254 | 0.85 | TDP1 (0.51) | LMNAFDPSALDH1A1MAPTHPGD | |
| SCHEMBL13230081 | 0.85 | ALDH1A1 (0.48) | LMNAFDPSALDH1A1MAPTHPGD | |
| SCHEMBL19557490 | 0.84 | ALDH1A1 (0.44) | LMNAFDPSALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9846168-B2 | Fluorescent metal ion indicators with large stokes shifts | Life Technologies Corporation (US) | 2017-12-19 | — | — | US | disclosed |
| US-9846168-B2 | Fluorescent metal ion indicators with large stokes shifts | Life Technologies Corporation (US) | 2017-12-19 | — | — | US | disclosed |
| US-20160305964-A1 | Fluorescent Metal Ion Indicators with Large Stokes Shifts | MOLECULAR PROBES, INC. | 2016-10-20 | — | — | US | disclosed |
| US-20160305964-A1 | Fluorescent Metal Ion Indicators with Large Stokes Shifts | MOLECULAR PROBES, INC. | 2016-10-20 | — | — | US | disclosed |
| US-9372181-B2 | Fluorescent metal ion indicators with large stokes shifts | Life Technologies Corporation (US) | 2016-06-21 | — | — | US | disclosed |
| US-9372181-B2 | Fluorescent metal ion indicators with large stokes shifts | Life Technologies Corporation (US) | 2016-06-21 | — | — | US | disclosed |
| US-9341631-B2 | Long wavelength fluorogenic intracellular ion indicators that are well retained in the cytosol | Life Technologies Corporation (US) | 2016-05-17 | — | — | US | disclosed |
| US-9341631-B2 | Long wavelength fluorogenic intracellular ion indicators that are well retained in the cytosol | Life Technologies Corporation (US) | 2016-05-17 | — | — | US | disclosed |
| US-20140363824-A1 | Fluorescent Metal Ion Indicators with Large Stokes Shifts | MOLECULAR PROBES, INC. | 2014-12-11 | — | — | US | disclosed |
| US-20140363839-A1 | LONG WAVELENGTH FLUOROGENIC INTRACELLULAR ION INDICATORS THAT ARE WELL RETAINED IN THE CYTOSOL | Life Technologies Corporation (US) | 2014-12-11 | — | — | US | disclosed |
| US-8785208-B2 | Fluorescent metal ion indicators with large stokes shifts | Life Technologies Corporation (US) | 2014-07-22 | — | — | US | disclosed |
| US-8785208-B2 | Fluorescent metal ion indicators with large stokes shifts | Life Technologies Corporation (US) | 2014-07-22 | — | — | US | disclosed |
| US-20130096300-A1 | LONG WAVELENGTH FLUOROGENIC INTRACELLULAR ION INDICATORS THAT ARE WELL RETAINED IN THE CYTOSOL | Life Technologies Corporation (US) | 2013-04-18 | — | — | US | disclosed |
| US-20130096300-A1 | LONG WAVELENGTH FLUOROGENIC INTRACELLULAR ION INDICATORS THAT ARE WELL RETAINED IN THE CYTOSOL | Life Technologies Corporation (US) | 2013-04-18 | — | — | US | disclosed |
| US-8318502-B2 | Long wavelength fluorogenic intracellular ion indicators that are well retained in the cytosol | Life Technologies Corporation (US) | 2012-11-27 | — | — | US | disclosed |
| US-20120009683-A1 | Fluorescent Metal Ion Indicators with Large Stokes Shifts | Life Technologies Corporation (US) | 2012-01-12 | — | — | US | disclosed |
| US-20100330584-A1 | LONG WAVELENGTH FLUOROGENIC INTRACELLULAR ION INDICATORS THAT ARE WELL RETAINED IN THE CYTOSOL | Life Technologies Corporation (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100196922-A1 | FLUORESCENT METAL ION INDICATORS WITH LARGE STOKES SHIFTS | Life Technologies Corporation (US) | 2010-08-05 | — | — | US | disclosed |
| US-20090029389-A1 | FLUORESCENT METAL ION INDICATORS WITH LARGE STOKES SHIFTS | INVITROGEN CORPORATION (US) | 2009-01-29 | — | — | US | disclosed |
| EP-0178775-B1 | FLUORESCENT INDICATOR DYES FOR CALCIUM IONS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1988-11-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100330584-A1 | LONG WAVELENGTH FLUOROGENIC INTRACELLULAR ION INDICATORS THAT ARE WELL RETAINED IN THE CYTOSOL | CHERP, MCU, GLB1 | LMNA 205/4885FDPS 2853/4885ALDH1A1 3508/4885 |
| US-20130096300-A1 | LONG WAVELENGTH FLUOROGENIC INTRACELLULAR ION INDICATORS THAT ARE WELL RETAINED IN THE CYTOSOL | CHERP, MCU, GLB1 | LMNA 205/4885FDPS 2853/4885ALDH1A1 3508/4885 |
| US-20120009683-A1 | Fluorescent Metal Ion Indicators with Large Stokes Shifts | SARAF, STIM1, ORAI1 | LMNA 2985/4885FDPS 2257/4885ALDH1A1 3754/4885 |
| US-20100196922-A1 | FLUORESCENT METAL ION INDICATORS WITH LARGE STOKES SHIFTS | SARAF, STIM1, ORAI1 | LMNA 2985/4885FDPS 2257/4885ALDH1A1 3754/4885 |
| US-20160305964-A1 | Fluorescent Metal Ion Indicators with Large Stokes Shifts | SARAF, STIM1, ORAI1 | LMNA 2985/4885FDPS 2257/4885ALDH1A1 3754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.