Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3894978 | 0.78 | ALDH1A1 (0.62) | ALOX15NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL3895951 | 0.75 | ALDH1A1 (0.58) | ALOX15NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL24097278 | 0.74 | ALOX15 (0.50) | ALOX15NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL3896087 | 0.73 | ALDH1A1 (0.47) | ALOX15NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL321553 | 0.73 | ALOX15 (0.48) | ALOX15NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL21824311 | 0.73 | ALOX15 (0.48) | ALOX15NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL9517185 | 0.73 | ALOX15 (0.48) | ALOX15NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL277387 | 0.73 | ALOX15 (0.48) | ALOX15NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL2010683 | 0.73 | ALOX15 (0.48) | ALOX15NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL15683854 | 0.73 | ALOX15 (0.48) | ALOX15NPC1RAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113563328-B | Preparation method of 1, 3-disubstituted-2-fluoro indolizine derivative | 台州学院 | 2022-07-05 | — | — | CN | disclosed |
| CN-113563328-B | Preparation method of 1, 3-disubstituted-2-fluoro indolizine derivative | 台州学院 | 2022-07-05 | — | — | CN | disclosed |
| CN-113563328-A | Preparation method of 1, 3-disubstituted-2-fluoro indolizine derivative | 台州学院 | 2021-10-29 | — | — | CN | disclosed |
| CN-113563328-A | Preparation method of 1, 3-disubstituted-2-fluoro indolizine derivative | 台州学院 | 2021-10-29 | — | — | CN | disclosed |
| WO-2014092478-A1 | ORGANIC COMPOUND, AND ORGANIC ELECTROLUMINESCENCE DEVICE COMPRISING SAME | 주식회사 두산 (KR) | 2014-06-19 | — | — | WO | disclosed |
| US-8748452-B2 | Indolizine derivative and use thereof for medical purposes | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2014-06-10 | — | — | US | disclosed |
| US-20120015972-A1 | INDOLIZINE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2012-01-19 | — | — | US | disclosed |
| US-20120015972-A1 | INDOLIZINE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015972-A1 | INDOLIZINE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES | XDH, INMT, PON1 | ALOX15 467/4885NPC1 567/4885RAB9A 3005/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.