Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.50 |
| ▸ | NOS2 | P35228 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.42 |
| ▸ | TPMT | P51580 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.39 |
| ▸ | IGFBP3 | P17936 | 2/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14136412 | 0.81 | ALOX15 (0.61) | ALOX15TSHRHIF1AHCAR2TPMT | |
| SCHEMBL1178906 | 0.80 | NOS2 (0.54) | NOS3NOS2ALOX15TSHRHIF1A | |
| SCHEMBL16232803 | 0.80 | NOS3 (0.46) | NOS3NOS2LMNAMRGPRX4RAB9A | |
| SCHEMBL1421848 | 0.79 | GPR35 (0.41) | ALOX15TSHRHIF1AHCAR2TPMT | |
| SCHEMBL3094908 | 0.79 | KDM4E (0.43) | ALOX15TSHRHIF1AHCAR2GPR35 | |
| Hydrochloric Acid SCHEMBL18640672 | 0.79 | ALOX15 (0.58) | ALOX15TSHRHIF1AHCAR2TPMT | |
| Hydrochloric Acid SCHEMBL1424993 | 0.79 | NOS2 (0.53) | NOS3NOS2ALOX15TSHRHIF1A | |
| SCHEMBL11303038 | 0.78 | KDM5C (0.38) | NOS3NOS2ALOX15TSHRHIF1A | |
| SCHEMBL6464978 | 0.76 | NOS2 (0.70) | NOS3NOS2NOS1 | |
| SCHEMBL17281038 | 0.76 | KMO (0.45) | ALOX15TSHRHIF1AHCAR2GPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028970-A1 | HETEROARYLTHIOMETHYL PYRIDINE DERIVATIVE | MSD K.K. (JP) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028970-A1 | HETEROARYLTHIOMETHYL PYRIDINE DERIVATIVE | AR, NR5A1, ARL1 | NOS3 4220/4885NOS2 4611/4885ALOX15 3316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.