Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 1/20 | 0.45 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.45 |
| ▸ | ACACB | O00763 | 2/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ACACA | Q13085 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20036657 | 0.83 | LPL (0.43) | LPLLIPGACACBESR1ESR2 | |
| SCHEMBL2641075 | 0.82 | ABCB11 (0.52) | ESR1ESR2ABCB11TRPA1 | |
| SCHEMBL10612175 | 0.81 | LPL (0.47) | LPLLIPGACACBESR1ESR2 | |
| SCHEMBL6182941 | 0.79 | TAAR1 (0.54) | LPLLIPGACACBESR1ESR2 | |
| SCHEMBL14540984 | 0.78 | LPL (0.48) | LPLLIPGACACBKMT2AACACA | |
| SCHEMBL4796978 | 0.78 | ADRB2 (0.48) | LPLLIPGACACBKMT2AACACA | |
| SCHEMBL7043601 | 0.78 | ADRB2 (0.48) | LPLLIPGACACBKMT2AACACA | |
| SCHEMBL597719 | 0.78 | IDO1 (0.50) | LPLLIPGACACBKMT2AACACA | |
| SCHEMBL9621041 | 0.78 | LPL (0.46) | LPLLIPGACACBESR1ESR2 | |
| SCHEMBL1954272 | 0.77 | ESR1 (0.79) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1820503-B1 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them | PFIZER ITALIA SRL (IT) | 2012-02-22 | — | — | EP | disclosed |