SCHEMBL10133862

SCHEMBL10133862

Cc1ccc2c(c1)sc1cc(-c3ccc4c(c3)sc3cc(C)ccc34)ccc12

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCL2L1 Q07817 1/20 0.44
MCL1 Q07820 1/20 0.44
APP P05067 7/20 0.40
MAPT P10636 7/20 0.40
RAB9A P51151 6/20 0.40
NPC1 O15118 4/20 0.40
GAA P10253 2/20 0.40
KDM4E B2RXH2 2/20 0.40
GLA P06280 1/20 0.40
LMNA P02545 2/20 0.38
ESR1 P03372 1/20 0.38
SNCA P37840 3/20 0.38
TNF P01375 1/20 0.37
NOD1 Q9Y239 1/20 0.37
SMN1; SMN2 Q16637 2/20 0.36
ALDH1A1 P00352 1/20 0.36
HPGD P15428 1/20 0.36
TP53 P04637 1/20 0.36
BCHE P06276 1/20 0.36
MEN1 O00255 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15599403 0.96 MCL1 (0.42) BCL2L1MCL1APPMAPTRAB9A
SCHEMBL15599413 0.92 MCL1 (0.40) BCL2L1MCL1APPMAPTRAB9A
SCHEMBL14680638 0.91 ESR1 (0.41) BCL2L1MCL1MAPTRAB9ALMNA
SCHEMBL812518 0.91 BCL2L1 (0.50) BCL2L1MCL1MAPTRAB9ANPC1
SCHEMBL14295769 0.90 LIMK1 (0.44) BCL2L1MCL1MAPTRAB9ANPC1
SCHEMBL10133864 0.90 BCL2L1 (0.38) BCL2L1MCL1APPMAPTRAB9A
SCHEMBL10133866 0.90 BCL2L1 (0.41) BCL2L1MCL1APPMAPTRAB9A
SCHEMBL25517166 0.89 BCL2L1 (0.38) BCL2L1MCL1APPMAPTRAB9A
SCHEMBL18267852 0.87 ESR1 (0.40) BCL2L1MCL1MAPTRAB9ALMNA
SCHEMBL25811188 0.86 ESR1 (0.37) BCL2L1MCL1MAPTRAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150129861-A1 ORGANIC MATERIAL FOR DEPOSITION, AND ORGANIC PHOTOELECTRIC CONVERSION ELEMENT, IMAGING ELEMENT, DEPOSITION METHOD, AND MANUFACTURING METHOD FOR ORGANIC PHOTOELECTRONIC ONVERSION ELEMENT OBTAINED USING THE SAME FUJIFILM CORPORATION (JP) 2015-05-14 US disclosed
US-8847141-B2 Photoelectric conversion element, production method thereof, photosensor, imaging device and their driving method FUJIFILM CORPORATION (JP) 2014-09-30 US disclosed
US-20140042411-A1 METHOD FOR PURIFYING ORGANIC MATERIAL, MATERIAL FOR ORGANIC ELECTRONICS, PHOTOELECTRIC CONVERSION DEVICE, OPTICAL SENSOR, IMAGING DEVICE, AND ORGANIC ELECTROLUMINESCENCE DEVICE FUJIFILM CORPORATION (JP) 2014-02-13 US disclosed
US-8637860-B2 Photoelectric conversion device, production method thereof, photosensor, imaging device and their drive methods FUJIFILM CORPORATION (JP) 2014-01-28 US disclosed
US-20130122276-A1 PHOTOELECTRIC CONVERSION DEVICE, PRODUCTION METHOD THEREOF, PHOTOSENSOR, IMAGING DEVICE AND THEIR DRIVE METHODS FUJIFILM CORPORATION (JP) 2013-05-16 US disclosed
US-8378339-B2 Photoelectric conversion device, production method thereof, photosensor, imaging device and their drive methods FUJIFILM CORPORATION (JP) 2013-02-19 US disclosed
US-20120080585-A1 PHOTOELECTRIC CONVERSION ELEMENT, PRODUCTION METHOD THEREOF, PHOTOSENSOR, IMAGING DEVICE AND THEIR DRIVING METHOD FUJIFILM CORPORATION (JP) 2012-04-05 US disclosed
US-20110063485-A1 PHOTOELECTRIC CONVERSION DEVICE, PRODUCTION METHOD THEREOF, PHOTOSENSOR, IMAGING DEVICE AND THEIR DRIVE METHODS FUJIFILM CORPORATION (JP) 2011-03-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120080585-A1 PHOTOELECTRIC CONVERSION ELEMENT, PRODUCTION METHOD THEREOF, PHOTOSENSOR, IMAGING DEVICE AND THEIR DRIVING METHOD SUN2, CYBA, PPOX BCL2L1 4273/4885MCL1 4751/4885APP 630/4885
US-20110063485-A1 PHOTOELECTRIC CONVERSION DEVICE, PRODUCTION METHOD THEREOF, PHOTOSENSOR, IMAGING DEVICE AND THEIR DRIVE METHODS PPOX, CRY1, FTO BCL2L1 3704/4885MCL1 4269/4885APP 977/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.