SCHEMBL10136313

SCHEMBL10136313

Cc1cc(Cl)cc(C(=O)NC(C)C)c1NC(=O)c1cc(CNS(=O)(=O)c2c(C(F)(F)F)cccc2C(F)(F)F)nn1-c1ncccc1Cl

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 2/20 0.36
ALDH1A1 P00352 2/20 0.33
TRPV1 Q8NER1 1/20 0.33
LMNA P02545 1/20 0.33
P2RX7 Q99572 1/20 0.33
SCN9A Q15858 4/20 0.32
NTRK1 P04629 2/20 0.32
MALT1 Q9UDY8 1/20 0.32
DHODH Q02127 2/20 0.32
TP53 P04637 1/20 0.32
SCN5A Q14524 2/20 0.32
CTSS P25774 1/20 0.31
CTSK P43235 1/20 0.31
BCL2L1 Q07817 1/20 0.31
MCL1 Q07820 1/20 0.31
MAPK13 O15264 1/20 0.31
MAPK12 P53778 1/20 0.31
MAPK11 Q15759 1/20 0.31
MAPK14 Q16539 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10136606 0.93 HTR6 (0.37) HTR6ALDH1A1LMNAP2RX7SCN9A
SCHEMBL10136248 0.91 LMNA (0.41) HTR6ALDH1A1LMNANTRK1TP53
SCHEMBL10136627 0.90 ALDH1A1 (0.39) HTR6ALDH1A1LMNANTRK1MALT1
SCHEMBL10136243 0.90 ALDH1A1 (0.40) HTR6ALDH1A1LMNANTRK1DHODH
SCHEMBL10136242 0.90 GRM4 (0.34) ALDH1A1TRPV1LMNAP2RX7SCN9A
SCHEMBL10136626 0.90 POLB (0.37) HTR6ALDH1A1LMNASCN9ADHODH
SCHEMBL10118322 0.89 ALDH1A1 (0.35) HTR6ALDH1A1LMNADHODHTP53
SCHEMBL10136612 0.89 ALDH1A1 (0.35) HTR6ALDH1A1TRPV1LMNADHODH
SCHEMBL10136917 0.88 HTR6 (0.43) HTR6ALDH1A1LMNATP53
SCHEMBL10136915 0.88 TP53 (0.36) HTR6ALDH1A1LMNATP53MCL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2582688-B1 ANTHRANILIC ACID DIAMIDE DERIVATIVES BAYER IP GMBH (DE) 2015-10-07 EP disclosed
US-8791139-B2 Anthranilic diamide derivatives BAYER CROPSCIENCE AG (DE) 2014-07-29 US disclosed
US-20120015980-A1 ANTHRANILIC DIAMIDE DERIVATIVES BAYER CROPSCIENCE AG (DE) 2012-01-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120015980-A1 ANTHRANILIC DIAMIDE DERIVATIVES DDT, QDPR, ANTXR2 HTR6 4439/4885ALDH1A1 732/4885TRPV1 2761/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.