SCHEMBL10136626

SCHEMBL10136626

Cc1cc(Cl)cc(C(=O)NC(C)C)c1NC(=O)c1cc(CNS(=O)(=O)c2cccc(C(F)(F)F)c2)nn1-c1ncccc1Cl

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.37
RECQL P46063 1/20 0.37
KCNA5 P22460 1/20 0.36
HTR6 P50406 1/20 0.35
TP53 P04637 1/20 0.35
ALDH1A1 P00352 2/20 0.35
KMT2A Q03164 2/20 0.34
MEN1 O00255 1/20 0.34
MAPT P10636 2/20 0.34
PDK1 Q15118 1/20 0.34
PDK2 Q15119 1/20 0.34
PDK3 Q15120 1/20 0.34
PDK4 Q16654 1/20 0.34
ELANE P08246 1/20 0.34
DHODH Q02127 1/20 0.34
BCL2L1 Q07817 1/20 0.34
MCL1 Q07820 1/20 0.34
LMNA P02545 1/20 0.34
SLC20A2 Q08357 1/20 0.34
SLC20A1 Q8WUM9 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10118322 0.95 ALDH1A1 (0.35) HTR6TP53ALDH1A1MAPTPDK1
SCHEMBL10136612 0.93 ALDH1A1 (0.35) HTR6TP53ALDH1A1MAPTPDK1
SCHEMBL10136917 0.92 HTR6 (0.43) HTR6TP53ALDH1A1KMT2AMEN1
SCHEMBL10136248 0.92 LMNA (0.41) POLBHTR6TP53ALDH1A1MAPT
SCHEMBL10136217 0.91 GRM4 (0.36) ALDH1A1KMT2AMEN1DHODHLMNA
SCHEMBL10136314 0.91 HTR6 (0.39) POLBHTR6TP53ALDH1A1MCL1
SCHEMBL10136627 0.90 ALDH1A1 (0.39) HTR6ALDH1A1ELANEDHODHLMNA
SCHEMBL10136243 0.90 ALDH1A1 (0.40) HTR6ALDH1A1KMT2AMEN1MAPT
SCHEMBL10136313 0.90 HTR6 (0.36) HTR6TP53ALDH1A1DHODHBCL2L1
SCHEMBL10136915 0.89 TP53 (0.36) POLBHTR6TP53ALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8791139-B2 Anthranilic diamide derivatives BAYER CROPSCIENCE AG (DE) 2014-07-29 US disclosed
US-20120015980-A1 ANTHRANILIC DIAMIDE DERIVATIVES BAYER CROPSCIENCE AG (DE) 2012-01-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120015980-A1 ANTHRANILIC DIAMIDE DERIVATIVES DDT, QDPR, ANTXR2 POLB 4330/4885RECQL 21/4885KCNA5 838/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.