SCHEMBL10140249

SCHEMBL10140249

CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCCNC(=O)CCCCC1SC[C@@H]2NC(=O)N[C@H]12)OC(=O)CCCCCCCCCCCCCCC

nearest known ligand 0.66

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ CNR2 P34972 2/20 0.66
▸ CNR1 P21554 3/20 0.61
▸ F2 P00734 1/20 0.55
▸ PRSS1 P07477 1/20 0.55
▸ PRSS2 P07478 1/20 0.55
▸ PRSS3 P35030 1/20 0.55
▸ TPSAB1 Q15661 1/20 0.55
▸ PLCD1 P51178 1/20 0.54
▸ NAPEPLD Q6IQ20 1/20 0.51
▸ FABP3 P05413 1/20 0.49
▸ TDP1 Q9NUW8 2/20 0.49
▸ HLCS P50747 2/20 0.46
▸ LPAR1 Q92633 2/20 0.46
▸ LPAR3 Q9UBY5 2/20 0.46
▸ SMPD1 P17405 1/20 0.46
▸ HPSE Q9Y251 1/20 0.46
▸ FOLH1 Q04609 2/20 0.45
▸ ENPP2 Q13822 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30165784 1.00 CNR2 (0.66) CNR2CNR1F2PRSS1PRSS2
SCHEMBL12989865 0.99 CNR2 (0.68) CNR2CNR1F2PRSS1PRSS2
SCHEMBL16419858 0.94 CNR2 (0.59) CNR2CNR1F2PRSS1PRSS2
SCHEMBL28660549 0.94 CNR2 (0.59) CNR2CNR1F2PRSS1PRSS2
SCHEMBL29688513 0.94 CNR2 (0.78) CNR2CNR1F2PRSS1PRSS2
SCHEMBL12582940 0.93 CNR2 (0.66) CNR2CNR1F2PRSS1PRSS2
SCHEMBL15746589 0.92 CNR1 (0.64) CNR2CNR1F2PRSS1PRSS2
SCHEMBL29758823 0.91 CNR2 (0.64) CNR2CNR1F2PRSS1PRSS2
SCHEMBL29910364 0.90 CNR2 (0.73) CNR2CNR1F2PRSS1PRSS2
SCHEMBL29700479 0.90 CNR2 (0.67) CNR2CNR1F2PRSS1PRSS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10004686-B2 Lipid construct for delivery of insulin to a mammal SDG, INC. (US) 2018-06-26 — — US disclosed
US-9943602-B2 Orally bioavailable lipid-based constructs SDG, INC. (US) 2018-04-17 — — US disclosed
US-9145453-B2 Orally bioavailable lipid-based constructs SDG, INC. (US) 2015-09-29 — — US disclosed
US-20150125518-A1 ORALLY BIOAVAILABLE LIPID-BASED CONSTRUCTS SDG, INC. 2015-05-07 — — US disclosed
US-8962015-B2 Orally bioavailable lipid-based constructs SDG, INC. (US) 2015-02-24 — — US disclosed
US-8846053-B2 Orally bioavailable lipid-based constructs SDG, INC. (US) 2014-09-30 — — US disclosed
US-20140243430-A1 ORALLY BIOAVAILABLE LIPID-BASED CONSTRUCTS SDG, INC. (US) 2014-08-28 — — US disclosed
US-20130267462-A1 Lipid Construct for Delivery of Insulin to a Mammal SDG, INC. 2013-10-10 — — US disclosed
US-20130183270-A1 Orally Bioavailable Lipid-Based Constructs SDG, INC. (US) 2013-07-18 — — US disclosed
US-20120035105-A1 Insulin Therapies for the Treatment of Diabetes, Diabetes Related Ailments, and/or Diseases or Conditions Other Than Diabetes or Diabetes Related Ailments SDG, INC. 2012-02-09 — — US disclosed
US-20100310599-A1 Orally Bioavailable Lipid-Based Constructs SDG, INC. 2010-12-09 — — US disclosed
US-20100247625-A1 Orally Bioavailable Lipid-Based Constructs SDG, INC. 2010-09-30 — — US disclosed
US-20100129428-A1 SUPRA MOLECULAR CONSTRUCT FOR DELIVERY OF INTERFERON TO A MAMMAL SDG, INC. 2010-05-27 — — US disclosed
US-20100080773-A1 Orally Bioavailable Lipid-Based Constructs SDG, INC. 2010-04-01 — — US disclosed
US-20090087479-A1 Orally bioavailable lipid-based constructs SDG, INC. ( AN OHIO CORPORATION) (US) 2009-04-02 — — US disclosed
US-20070218117-A1 Supra molecular construct for delivery of interferon to a mammal SDG, INC. 2007-09-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070218117-A1 Supra molecular construct for delivery of interferon to a mammal HAVCR2, IFNAR1, MSR1 CNR2 2404/4885CNR1 1331/4885F2 2393/4885
US-20100080773-A1 Orally Bioavailable Lipid-Based Constructs FABP2, FABP1, LIPC CNR2 1029/4885CNR1 1065/4885F2 2252/4885
US-20100129428-A1 SUPRA MOLECULAR CONSTRUCT FOR DELIVERY OF INTERFERON TO A MAMMAL HAVCR2, IFNAR1, IFNG CNR2 2524/4885CNR1 1514/4885F2 2498/4885
US-20150125518-A1 ORALLY BIOAVAILABLE LIPID-BASED CONSTRUCTS FABP2, FABP1, FABP6 CNR2 721/4885CNR1 464/4885F2 2636/4885
US-10004686-B2 Lipid construct for delivery of insulin to a mammal INSR, IAPP, GPR119 CNR2 1119/4885CNR1 719/4885F2 2597/4885
US-20130183270-A1 Orally Bioavailable Lipid-Based Constructs FABP2, FABP1, LIPC CNR2 1029/4885CNR1 1065/4885F2 2252/4885
US-20100310599-A1 Orally Bioavailable Lipid-Based Constructs FABP2, LIPC, FABP6 CNR2 604/4885CNR1 795/4885F2 1894/4885
US-20090087479-A1 Orally bioavailable lipid-based constructs FABP2, FABP1, FABP6 CNR2 670/4885CNR1 775/4885F2 2357/4885
US-20120035105-A1 Insulin Therapies for the Treatment of Diabetes, Diabetes Related Ailments, and/or Diseases or Conditions Other Than Diabetes or Diabetes Related Ailments IAPP, IDE, INSR CNR2 1363/4885CNR1 1436/4885F2 739/4885
US-20140243430-A1 ORALLY BIOAVAILABLE LIPID-BASED CONSTRUCTS FABP2, LIPC, FABP6 CNR2 604/4885CNR1 795/4885F2 1894/4885
US-20100247625-A1 Orally Bioavailable Lipid-Based Constructs FABP2, LIPC, FABP6 CNR2 604/4885CNR1 795/4885F2 1894/4885
US-20130267462-A1 Lipid Construct for Delivery of Insulin to a Mammal INSR, IAPP, GPR119 CNR2 1119/4885CNR1 719/4885F2 2597/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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