Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 2/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL890254 | 0.82 | LMNA (0.36) | P4HTMESR1ESR2KDM4ECHRNA7 | |
| SCHEMBL889328 | 0.81 | TUBB4A (0.33) | ESR1ESR2CHRNA7 | |
| SCHEMBL19116260 | 0.79 | GRM5 (0.49) | MAPK1KDM4ECHRNA7NPC1MTOR | |
| SCHEMBL12842147 | 0.79 | CHRNB2 (0.34) | ESR1ESR2CHRNA7 | |
| SCHEMBL9837728 | 0.79 | P4HTM (0.58) | P4HTMESR1ESR2MAPK1KDM4E | |
| SCHEMBL5511343 | 0.79 | P4HTM (0.58) | P4HTMESR1ESR2MAPK1KDM4E | |
| SCHEMBL13881346 | 0.79 | GLA (0.46) | P4HTMESR1MAPK1KDM4EPANK3 | |
| SCHEMBL12074871 | 0.76 | PAM (0.50) | P4HTMESR1MAPK1KDM4EPANK3 | |
| SCHEMBL2555492 | 0.76 | TYR (0.48) | KDM4ECHRNA7HSD17B10 | |
| SCHEMBL30453932 | 0.76 | TYR (0.48) | KDM4ECHRNA7HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021704-A1 | HEPATITIS C VIRUS INHIBITORS | ENANTA PHARMACEUTICALS, INC. (US) | 2012-02-16 | — | — | WO | disclosed |
| WO-2011091417-A1 | HEPATITIS C VIRUS INHIBITORS | ENANTA PHARMACEUTICALS, INC. (US) | 2011-07-28 | — | — | WO | disclosed |
| WO-2011081918-A1 | HEPATITIS C VIRUS INHIBITORS | ENANTA PHARMACEUTICALS, INC (US) | 2011-07-07 | — | — | WO | disclosed |
| WO-2011031934-A1 | HEPATITIS C VIRUS INHIBITORS | ENANTA PHARMACEUTICALS, INC. (US) | 2011-03-17 | — | — | WO | disclosed |