Sugi Predict

Sugi Predict / Compounds / SCHEMBL10145674

SCHEMBL10145674

SCHEMBL10145674

COCOc1cc2c(cc1Cl)C1(OC(=O)c3ccccc31)c1ccc3cc(OS(=O)(=O)C(F)(F)F)ccc3c1O2

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP3A4 P08684 1/20 0.41
▸ MEN1 O00255 2/20 0.37
▸ MAPT P10636 2/20 0.37
▸ HTT P42858 2/20 0.37
▸ KMT2A Q03164 2/20 0.37
▸ USP2 O75604 1/20 0.37
▸ ALDH1A1 P00352 1/20 0.37
▸ LMNA P02545 1/20 0.37
▸ FTO Q9C0B1 2/20 0.33
▸ PRMT1 Q99873 2/20 0.33
▸ HPGD P15428 1/20 0.33
▸ CYP2C19 P33261 1/20 0.33
▸ RECQL P46063 1/20 0.33
▸ BLM P54132 1/20 0.33
▸ SMAD3 P84022 1/20 0.33
▸ ACE2 Q9BYF1 1/20 0.33
▸ TDP1 Q9NUW8 1/20 0.33
▸ GNG2 P59768 1/20 0.32
▸ GNB1 P62873 1/20 0.32
▸ GSTP1 P09211 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10145566 0.87 CYP3A4 (0.46) CYP3A4MEN1MAPTHTTKMT2A
SCHEMBL10145582 0.86 CYP3A4 (0.44) CYP3A4MEN1MAPTHTTKMT2A
SCHEMBL10145671 0.85 FTO (0.48) CYP3A4MEN1MAPTHTTKMT2A
SCHEMBL10145679 0.84 CYP3A4 (0.43) CYP3A4MEN1MAPTHTTKMT2A
SCHEMBL24972170 0.83 GNG2 (0.45) CYP3A4MEN1MAPTHTTKMT2A
SCHEMBL31063708 0.80 CYP3A4 (0.49) CYP3A4MEN1MAPTHTTKMT2A
SCHEMBL10103166 0.79 CYP3A4 (0.64) CYP3A4MEN1MAPTHTTKMT2A
SCHEMBL10145577 0.74 CYP3A4 (0.48) CYP3A4MEN1MAPTHTTKMT2A
SCHEMBL10145564 0.74 CYP3A4 (0.48) CYP3A4MEN1MAPTHTTKMT2A
SCHEMBL28503884 0.73 CYP3A4 (0.62) CYP3A4MEN1MAPTHTTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8114904-B2 Luminescence quenchers and fluorogenic probes for detection of reactive species Versitech Limited & Morningside Ventures Limited (CN) 2012-02-14 — — US disclosed
US-8114904-B2 Luminescence quenchers and fluorogenic probes for detection of reactive species Versitech Limited & Morningside Ventures Limited (CN) 2012-02-14 — — US disclosed
US-20090253118-A1 LUMINESCENCE QUENCHERS AND FLUOROGENIC PROBES FOR DETECTION OF REACTIVE SPECIES VERSITECH LIMITED (CN) 2009-10-08 — — US disclosed
US-20090253118-A1 LUMINESCENCE QUENCHERS AND FLUOROGENIC PROBES FOR DETECTION OF REACTIVE SPECIES VERSITECH LIMITED (CN) 2009-10-08 — — US disclosed
WO-2009121247-A1 LUMINESCENCE QUENCHERS AND FLUOROGENIC PROBES FOR DETECTION OF REACTIVE SPECIES VERSITECH LIMITED (CN) 2009-10-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090253118-A1 LUMINESCENCE QUENCHERS AND FLUOROGENIC PROBES FOR DETECTION OF REACTIVE SPECIES ROS1, LPO, HMOX1 CYP3A4 508/4885MEN1 4478/4885MAPT 4349/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.