Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.47 |
| ▸ | PARG | Q86W56 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 2/20 | 0.41 |
| ▸ | AGER | Q15109 | 1/20 | 0.40 |
| ▸ | HPD | P32754 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | PDE2A | O00408 | 5/20 | 0.39 |
| ▸ | PDE1A | P54750 | 5/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 5/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 5/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10145948 | 0.85 | GRM2 (0.49) | GRM2METAP2HPDMAPK14CHEK1 | |
| SCHEMBL10145941 | 0.82 | GRM2 (0.47) | GRM2ALDH1A1METAP2HPDMAPK14 | |
| SCHEMBL10146668 | 0.82 | GRM2 (0.70) | GRM2PARGMETAP2 | |
| SCHEMBL10145950 | 0.82 | MAPK14 (0.53) | GRM2ALDH1A1BRD4METAP2MAPK14 | |
| SCHEMBL627494 | 0.82 | GRM2 (0.44) | GRM2PARGBRD4AGERHPD | |
| SCHEMBL10145952 | 0.81 | GRM2 (0.45) | GRM2METAP2MAPK14 | |
| SCHEMBL10146004 | 0.80 | BRD4 (0.48) | GRM2PARGALDH1A1BRD4HPD | |
| SCHEMBL10146671 | 0.80 | PARG (0.51) | GRM2PARGMETAP2MAPK14CHEK1 | |
| SCHEMBL8229445 | 0.76 | AGER (0.62) | PARGALDH1A1AGERHPDLMNA | |
| SCHEMBL10146391 | 0.76 | TRIM24 (0.40) | GRM2PARGALDH1A1BRD4HPD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | disclosed |