Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4761500 | 0.82 | SIRT6 (0.48) | KDM4EMAPK1HIF1AFOLH1 | |
| SCHEMBL6754720 | 0.73 | NPSR1 (0.45) | MAPK1HIF1AMTNR1AMTNR1BMAPT | |
| SCHEMBL13025173 | 0.73 | SIRT5 (0.41) | KDM4EMAPK1HIF1AFOLH1 | |
| SCHEMBL11911312 | 0.71 | MGLL (0.59) | KDM4EMAPK1HIF1AOPRM1OPRD1 | |
| SCHEMBL25550072 | 0.71 | MAPK1 (0.54) | KDM4EMAPK1HIF1APAOXFOLH1 | |
| SCHEMBL14016183 | 0.70 | AKT1 (0.40) | AKT1 | |
| SCHEMBL12910864 | 0.69 | SIRT5 (0.42) | KDM4EMAPK1HIF1AFOLH1 | |
| SCHEMBL10147906 | 0.69 | HIF1A (0.42) | KDM4EMAPK1HIF1APAOXNAMPT | |
| SCHEMBL13499241 | 0.68 | SIRT5 (0.43) | OPRM1OPRD1OPRK1FOLH1AKT1 | |
| SCHEMBL12697308 | 0.67 | MTNR1A (0.56) | KDM4EMAPK1HIF1AOPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106131-B2 | Hydrolytically stable maleimide-terminated polymers | NEKTAR THERAPEUTICS (US) | 2012-01-31 | — | — | US | disclosed |
| US-20090012241-A1 | Hydrolytically stable maleimide-terminated polymers | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2009-01-08 | — | — | US | disclosed |