SCHEMBL10148817

SCHEMBL10148817

C=C(C)C(=O)Nc1cccc(NC(=O)C(=C)C)n1

nearest known ligand 0.64

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.51
KDM4E B2RXH2 2/20 0.49
LMNA P02545 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
MEN1 O00255 2/20 0.48
KMT2A Q03164 2/20 0.48
RAB9A P51151 2/20 0.48
HPGD P15428 1/20 0.48
RXFP1 Q9HBX9 3/20 0.46
POLB P06746 1/20 0.44
GAA P10253 1/20 0.44
RECQL P46063 1/20 0.44
BLM P54132 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
MAPK8 P45983 1/20 0.44
GRM5 P41594 1/20 0.43
ALDH1A1 P00352 2/20 0.43
NPC1 O15118 1/20 0.42
PKM P14618 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22111560 0.91 TDP1 (0.45) TDP1KDM4ELMNASMN1; SMN2MEN1
SCHEMBL11964356 0.89 TDP1 (0.46) TDP1KDM4ELMNASMN1; SMN2MEN1
SCHEMBL6663529 0.89 RAB9A (0.66) SMN1; SMN2MEN1KMT2ARAB9AGRM5
SCHEMBL14294321 0.88 XIAP (0.58) TDP1KDM4ELMNASMN1; SMN2MEN1
SCHEMBL4360862 0.79 NPC1 (0.72) KDM4ELMNASMN1; SMN2MEN1KMT2A
SCHEMBL13609769 0.79 NPC1 (0.58) SMN1; SMN2KMT2ARAB9ANPC1
SCHEMBL821844 0.79 KDM4E (0.71) KDM4ELMNASMN1; SMN2MEN1KMT2A
SCHEMBL7093180 0.78 CYP1A2 (0.49) TDP1LMNAKMT2ARAB9ARXFP1
SCHEMBL20803409 0.77 TDP1 (0.37) TDP1KDM4ELMNAKMT2ARAB9A
SCHEMBL11728058 0.77 MEN1 (0.59) TDP1KDM4ELMNASMN1; SMN2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10772822-B2 Molecularly imprinted polymers and their use as antidandruff agents L'OREAL (FR) 2020-09-15 US claimed
EP-2938641-B1 MOLECULARLY IMPRINTED POLYMERS AND THEIR USE AS ANTIDANDRUFF AGENTS ORÉAL L (FR) 2016-08-24 EP claimed
US-20150342859-A1 MOLECULARLY IMPRINTED POLYMERS AND THEIR USE AS ANTIDANDRUFF AGENTS L'OREAL (FR) 2015-12-03 US claimed
US-20150320667-A1 MOLECULARLY IMPRINTED POLYMER FOR SELECTIVELY TRAPPING ODOROUS MOLECULES L'OREAL (FR) 2015-11-12 US claimed
US-20230190613-A1 SKIN PERFECTING COSMETIC COMPOSITIONS AND METHODS OF USE L'OREAL (FR) 2023-06-22 US disclosed
CN-109589943-B Method for preparing cadmium (II) ion imprinting composite membrane 昆明理工大学 2021-11-12 CN disclosed
US-10772823-B2 Molecularly imprinted polymer for selectively trapping odorous molecules L'OREAL (FR) 2020-09-15 US disclosed
US-10772822-B2 Molecularly imprinted polymers and their use as antidandruff agents L'OREAL (FR) 2020-09-15 US disclosed
US-20200188878-A1 MOLECULARLY IMPRINTED POLYMERS MONASH UNIVERSITY (AU) 2020-06-18 US disclosed
US-20200188878-A1 MOLECULARLY IMPRINTED POLYMERS MONASH UNIVERSITY (AU) 2020-06-18 US disclosed
US-20160288090-A1 MOLECULARLY IMPRINTED POLYMERS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2016-10-06 US disclosed
US-20160288090-A1 MOLECULARLY IMPRINTED POLYMERS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2016-10-06 US disclosed
US-20150320667-A1 MOLECULARLY IMPRINTED POLYMER FOR SELECTIVELY TRAPPING ODOROUS MOLECULES L'OREAL (FR) 2015-11-12 US disclosed
EP-2391658-B1 MOLECULARLY IMPRINTED POLYMERS COMMW SCIENT IND RES ORG (AU) 2015-09-23 EP disclosed
US-20120052757-A1 MOLECULARLY IMPRINTED POLYMERS MONASH UNIVERSITY (AU) 2012-03-01 US disclosed
US-20120052757-A1 MOLECULARLY IMPRINTED POLYMERS MONASH UNIVERSITY (AU) 2012-03-01 US disclosed
WO-2010085851-A1 MOLECULARLY IMPRINTED POLYMERS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2010-08-05 WO disclosed
US-7332553-B2 Functional monomers for molecular recognition and catalysis MIP TECHNOLOGIES AB (SE) 2008-02-19 US disclosed
US-20070106041-A1 Functional monomers for molecular recognition and catalysis MIP TECHNOLOGIES AB (SE) 2007-05-10 US disclosed
US-7208557-B2 Functional monomers for molecular recognition and catalysis MIP TECHNOLOGIES AB (SE) 2007-04-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10772822-B2 Molecularly imprinted polymers and their use as antidandruff agents DNMT1, POLR1C, ETF1 TDP1 763/4885KDM4E 2166/4885LMNA 3121/4885
US-20160288090-A1 MOLECULARLY IMPRINTED POLYMERS IPMK, MPI, PIM3 TDP1 2482/4885KDM4E 738/4885LMNA 3479/4885
US-20150342859-A1 MOLECULARLY IMPRINTED POLYMERS AND THEIR USE AS ANTIDANDRUFF AGENTS DNMT1, POLR1C, ETF1 TDP1 763/4885KDM4E 2166/4885LMNA 3121/4885
US-20070106041-A1 Functional monomers for molecular recognition and catalysis PCNA, MUS81, PNMT TDP1 2171/4885KDM4E 1566/4885LMNA 3374/4885
US-20120052757-A1 MOLECULARLY IMPRINTED POLYMERS IPMK, MPI, PIM3 TDP1 2482/4885KDM4E 738/4885LMNA 3479/4885
US-20230190613-A1 SKIN PERFECTING COSMETIC COMPOSITIONS AND METHODS OF USE CUTA, ELOVL3, ELOVL1 TDP1 1468/4885KDM4E 958/4885LMNA 1002/4885
US-20200188878-A1 MOLECULARLY IMPRINTED POLYMERS IPMK, MPI, PIM3 TDP1 2482/4885KDM4E 738/4885LMNA 3479/4885
US-10772823-B2 Molecularly imprinted polymer for selectively trapping odorous molecules OR10J3, OR51E2, MSMO1 TDP1 2821/4885KDM4E 3113/4885LMNA 4601/4885
US-20150320667-A1 MOLECULARLY IMPRINTED POLYMER FOR SELECTIVELY TRAPPING ODOROUS MOLECULES OR10J3, OR51E2, MSMO1 TDP1 2821/4885KDM4E 3113/4885LMNA 4601/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.