Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | GABRP | O00591 | 1/20 | 0.43 |
| ▸ | GABRD | O14764 | 1/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.43 |
| ▸ | ALB | P02768 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29544459 | 0.82 | OPRK1 (0.54) | OPRK1LMNAPDE3APDE4DHTR2B | |
| SCHEMBL1687457 | 0.82 | OPRK1 (0.54) | OPRK1LMNAPDE3APDE4DHTR2B | |
| SCHEMBL29410184 | 0.82 | OPRK1 (0.54) | OPRK1LMNAPDE3APDE4DHTR2B | |
| SCHEMBL10149194 | 0.80 | OPRK1 (0.56) | OPRK1LMNAPDE3APDE4DHTR2B | |
| SCHEMBL14536845 | 0.80 | OPRK1 (0.59) | OPRK1LMNAPDE3APDE4DHTR2B | |
| SCHEMBL9059928 | 0.79 | OPRK1 (0.62) | OPRK1LMNAPDE3APDE4DHTR2B | |
| SCHEMBL6124997 | 0.78 | LMNA (0.55) | OPRK1LMNAPDE4DALBCCKBR | |
| SCHEMBL10193351 | 0.77 | OPRK1 (0.60) | OPRK1LMNAPDE3APDE4DHTR2B | |
| SCHEMBL11964613 | 0.76 | OPRK1 (0.62) | OPRK1LMNAPDE3APDE4DHTR2B | |
| SCHEMBL10149097 | 0.75 | LMNA (0.49) | OPRK1LMNAPDE3APDE4DHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2062583-B1 | Therapeutic applications of pro-apoptotic benzodiazepines | UNIV MICHIGAN (US) | 2012-12-26 | — | — | EP | disclosed |
| EP-2422788-A2 | Benzodiazepines and compositions and uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-2359831-A2 | Therapeutic applications of pro-apoptotic benzodiazepines | The Regents of the University of Michigan (US) | 2011-08-24 | — | — | EP | disclosed |
| US-20090012065-A1 | Therapeutic applications of pro-apoptotic benzodiazepines | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-01-08 | — | — | US | disclosed |
| US-7220739-B2 | Therapeutic application of pro-apoptotic benzodiazepines | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2007-05-22 | — | — | US | disclosed |
| WO-2007053193-A2 | UNSOLVATED BENZODIAZEPINE COMPOSITIONS AND METHODS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2007-05-10 | — | — | WO | disclosed |
| US-20070036854-A1 | Therapeutic applications of pro-apoptotic benzodiazepines | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2007-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012065-A1 | Therapeutic applications of pro-apoptotic benzodiazepines | BAD, GABRB1, GABRA5 | OPRK1 40/4885LMNA 143/4885PDE3A 1765/4885 |
| US-20070036854-A1 | Therapeutic applications of pro-apoptotic benzodiazepines | BAD, GABRB1, GABRA5 | OPRK1 40/4885LMNA 143/4885PDE3A 1765/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.