Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17733612 | 1.00 | EPAS1 (0.32) | EPAS1HTR2CALDH1A1MAPK1 | |
| SCHEMBL943033 | 0.98 | EPAS1 (0.33) | EPAS1HTR2CALDH1A1 | |
| SCHEMBL6512104 | 0.93 | HTR2C (0.35) | HTR2C | |
| SCHEMBL20256032 | 0.89 | EPAS1 (0.35) | EPAS1HTR2CALDH1A1 | |
| SCHEMBL20121932 | 0.85 | CXCR4 (0.31) | EPAS1ALDH1A1 | |
| SCHEMBL5680966 | 0.84 | EPAS1 (0.35) | EPAS1 | |
| SCHEMBL2931996 | 0.84 | EPAS1 (0.33) | EPAS1ALDH1A1 | |
| SCHEMBL28119029 | 0.84 | EPAS1 (0.33) | EPAS1ALDH1A1 | |
| SCHEMBL13351747 | 0.84 | MBTD1 (0.36) | EPAS1 | |
| SCHEMBL4129266 | 0.84 | MBTD1 (0.36) | EPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023030388-A1 | 5-FLUORO-7H-PYRROLO[2,3-D] PYRIMIDINES COMPOUND AS WEE-1 INHIBITOR | 微境生物医药科技(上海)有限公司 | 2023-03-09 | — | — | WO | disclosed |
| US-8759340-B2 | Benzodiazepinone compounds useful in the treatment of skin conditions | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-06-24 | — | — | US | disclosed |
| US-8722667-B2 | Compositions and methods for inhibiting the proliferation of cells | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-05-13 | — | — | US | disclosed |
| US-20130274197-A1 | BENZODIAZEPINONE COMPOUNDS USEFUL IN THE TREATMENT OF SKIN CONDITIONS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-10-17 | — | — | US | disclosed |
| US-20130190300-A1 | COMPOSITIONS AND METHODS FOR INHIBITING THE PROLIFERATION OF CELLS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-07-25 | — | — | US | disclosed |
| EP-2604269-A1 | 1,4-benzodiazepine-2,5-diones with therapeutic properties | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-06-19 | — | — | EP | disclosed |
| US-8461153-B2 | Benzodiazepinone compounds useful in the treatment of skin conditions | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-06-11 | — | — | US | disclosed |
| EP-2422788-A2 | Benzodiazepines and compositions and uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1398033-B1 | Use of benzodiazepines for treating autoimmune diseases, inflammations, neoplasies, viral infections and atherosclerosis | UNIV MICHIGAN (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2007053725-A2 | NOVEL 1,4-BENZODIAZEPINE-2,5-DIONES WITH THERAPEUTIC PROPERTIES | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2007-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130190300-A1 | COMPOSITIONS AND METHODS FOR INHIBITING THE PROLIFERATION OF CELLS | BAX, BCL2, MKI67 | EPAS1 1695/4885HTR2C 1374/4885ALDH1A1 2177/4885 |
| US-20130274197-A1 | BENZODIAZEPINONE COMPOUNDS USEFUL IN THE TREATMENT OF SKIN CONDITIONS | RORC, RORA, RORB | EPAS1 1886/4885HTR2C 234/4885ALDH1A1 373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.