Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 3/20 | 0.37 |
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 10/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 10/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | GFER | P55789 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL646781 | 0.86 | STIM1 (0.42) | STIM1ORAI1ADORA2AADORA1GFER | |
| SCHEMBL10151672 | 0.83 | RAB9A (0.44) | NPC1RAB9AMEN1KMT2A | |
| SCHEMBL10151417 | 0.81 | MAPT (0.38) | NPC1RAB9AGFERTP53MEN1 | |
| SCHEMBL10151287 | 0.80 | BMI1 (0.34) | NPC1RAB9AGFERSMN1; SMN2TP53 | |
| SCHEMBL647785 | 0.79 | STIM1 (0.40) | STIM1ORAI1ADORA2AADORA1SMN1; SMN2 | |
| SCHEMBL647452 | 0.74 | LCK (0.38) | STIM1ORAI1ADORA2AADORA1RAB9A | |
| SCHEMBL10151674 | 0.72 | TP53 (0.38) | STIM1ORAI1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10151409 | 0.72 | ALDH1A1 (0.40) | ORAI1NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL645388 | 0.72 | STIM1 (0.40) | STIM1ORAI1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL647646 | 0.71 | STIM1 (0.38) | STIM1ORAI1ADORA2AADORA1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119643-B2 | Benzoimidazolyl-pyrazine compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2012-02-21 | — | — | US | disclosed |