Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMI1 | P35226 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL646766 | 0.87 | MEN1 (0.33) | HTTPIK3CDPIK3CAPIK3CBLCK | |
| SCHEMBL10151409 | 0.83 | ALDH1A1 (0.40) | BMI1NPC1RAB9ATP53LMNA | |
| SCHEMBL646986 | 0.81 | CACNA1D (0.35) | NPC1RAB9AGFERTP53HTT | |
| SCHEMBL10151679 | 0.80 | STIM1 (0.37) | NPC1RAB9AGFERTP53LMNA | |
| SCHEMBL10151417 | 0.80 | MAPT (0.38) | BMI1NPC1RAB9AGFERAPP | |
| SCHEMBL10151672 | 0.71 | RAB9A (0.44) | NPC1RAB9AMAPTPPARGKDM4E | |
| SCHEMBL10151674 | 0.71 | TP53 (0.38) | NPC1RAB9ATP53MAPTLMNA | |
| SCHEMBL646901 | 0.70 | KDM4E (0.38) | RAB9APPARGKDM4E | |
| SCHEMBL645672 | 0.69 | CRACR2A (0.41) | NPC1RAB9ATP53MAPTLMNA | |
| SCHEMBL645787 | 0.69 | IL1B (0.38) | NPC1RAB9AGFERLMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119643-B2 | Benzoimidazolyl-pyrazine compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2012-02-21 | — | — | US | disclosed |