Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10153371 | 0.76 | TSHR (0.38) | KMT2A | |
| SCHEMBL14459252 | 0.75 | KMT2A (0.58) | KMT2AMAPK1TDP1 | |
| SCHEMBL14459432 | 0.71 | KMT2A (0.44) | KMT2AMAPK1TDP1 | |
| SCHEMBL14648359 | 0.70 | MAPK1 (0.32) | MAPK1TDP1 | |
| SCHEMBL7931082 | 0.70 | MAPK1 (0.57) | MAPK1TDP1 | |
| SCHEMBL10153360 | 0.68 | AHR (0.35) | TDP1 | |
| SCHEMBL13648126 | 0.67 | HTR3E (0.53) | KMT2A | |
| SCHEMBL7092582 | 0.67 | ALDH1A1 (0.38) | KMT2A | |
| SCHEMBL85152 | 0.67 | MAPT (0.47) | KMT2ATDP1 | |
| SCHEMBL10153362 | 0.67 | ITGB3 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8329907-B2 | Autotaxin inhibitors | MERCK PATENT GMBH (DE) | 2012-12-11 | — | — | US | disclosed |
| US-20120015976-A1 | AUTOTAXIN INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANK TER HAFTUNG (DE) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015976-A1 | AUTOTAXIN INHIBITORS | ENPP2, PLA2G12A, LPCAT1 | KMT2A 1523/4885MAPK1 1634/4885TDP1 1108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.