Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9959313 | 0.88 | KCNA5 (0.48) | MAPTALDH1A1LMNAPOLBKMT2A | |
| SCHEMBL9959558 | 0.82 | KCNA5 (0.46) | MAPTALDH1A1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL9958824 | 0.82 | ALDH1A1 (0.44) | MAPTALDH1A1LMNAPOLBKMT2A | |
| SCHEMBL10153587 | 0.81 | MAPT (0.59) | MAPTALDH1A1LMNANPSR1GAA | |
| SCHEMBL9959297 | 0.81 | HDAC4 (0.49) | MAPTALDH1A1GAAPOLBKMT2A | |
| SCHEMBL10153642 | 0.81 | KCNA5 (0.42) | MAPTALDH1A1LMNANPSR1KMT2A | |
| SCHEMBL10153968 | 0.80 | FAAH (0.39) | MAPTALDH1A1LMNAKMT2AALOX15 | |
| SCHEMBL9959606 | 0.79 | NPC1 (0.52) | MAPTALDH1A1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL9958882 | 0.79 | KMT2A (0.46) | MAPTALDH1A1LMNANPSR1KMT2A | |
| SCHEMBL9959312 | 0.79 | DRD2 (0.41) | MAPTALDH1A1LMNAKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085003-A1 | 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONES AND RELATED COMPOUNDS USEFUL AS HIV REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-06-28 | — | — | WO | disclosed |