Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 4/20 | 0.52 |
| ▸ | MMP2 | P08253 | 3/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11834847 | 0.88 | MMP9 (0.50) | MMP9MMP2PTGS2PDE4APDE4B | |
| SCHEMBL11899995 | 0.82 | PARP10 (0.48) | — | |
| SCHEMBL5861 | 0.75 | FFAR1 (0.56) | FFAR1 | |
| SCHEMBL11829934 | 0.75 | MMP2 (0.50) | MMP9MMP2PTGS2FFAR1 | |
| SCHEMBL6074 | 0.75 | CA12 (0.46) | MMP9MMP8MMP13 | |
| SCHEMBL15422345 | 0.75 | MMP2 (0.44) | MMP9MMP2PTGS2MMP8 | |
| SCHEMBL10770 | 0.75 | MMP2 (0.47) | MMP9MMP2PTGS2FFAR1 | |
| SCHEMBL23174395 | 0.74 | CYP2C19 (0.46) | MMP2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL15422786 | 0.74 | ALDH1A1 (0.43) | MMP9MMP2PTGS2 | |
| SCHEMBL11831157 | 0.74 | MMP9 (0.55) | MMP9MMP2PTGS2PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488489-A2 | C-LINKED HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | Pfizer Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011045703-A2 | C-LINKED HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | PFIZER INC. (US) | 2011-04-21 | — | — | WO | disclosed |