Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15422345 | 0.80 | MMP2 (0.44) | ALDH1A1PTGS2RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL10158 | 0.74 | MMP9 (0.52) | PTGS2MMP2MMP9 | |
| SCHEMBL15422784 | 0.74 | NOTUM (0.48) | ALDH1A1PTGS2RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL5861 | 0.68 | FFAR1 (0.56) | ALDH1A1RAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL4050309 | 0.67 | CHRM2 (0.54) | ALDH1A1PTGS2CHRM2CHRM1DRD1 | |
| SCHEMBL11804742 | 0.67 | RAB9A (0.52) | ALDH1A1PTGS2CHRM2CHRM1DRD1 | |
| SCHEMBL16088990 | 0.67 | RAB9A (0.52) | ALDH1A1PTGS2CHRM2CHRM1DRD1 | |
| SCHEMBL18974099 | 0.67 | CHRM2 (0.54) | ALDH1A1PTGS2CHRM2CHRM1DRD1 | |
| SCHEMBL1854386 | 0.67 | L3MBTL1 (0.38) | ALDH1A1RAB9AKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL20668990 | 0.67 | CHRM2 (0.56) | ALDH1A1CHRM2CHRM1DRD1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8748466-B2 | Isoxazole derivatives useful as antibacterial agents | PFIZER INC. (US) | 2014-06-10 | — | — | US | disclosed |
| US-20140024690-A1 | Isoxazole Derivatives Useful As Antibacterial Agents | PFIZER INC. (US) | 2014-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140024690-A1 | Isoxazole Derivatives Useful As Antibacterial Agents | HAX1, PRXL2A, PRDX1 | ALDH1A1 2868/4885PTGS2 870/4885CHRM2 4880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.