Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 0.41 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.34 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18075374 | 0.84 | TRPA1 (0.41) | PDE2AHSPA5TRPA1CYP1A2CYP2A6 | |
| SCHEMBL21180454 | 0.84 | PDE2A (0.39) | PDE2ATRPA1CYP1A2CYP2A6SIGMAR1 | |
| SCHEMBL19398823 | 0.83 | HSPA5 (0.43) | PDE2AHSPA5TRPA1CYP1A2CYP2A6 | |
| SCHEMBL25530522 | 0.82 | ESR1 (0.42) | CYP1A2SIGMAR1CYP3A4MAPK1IDO1 | |
| SCHEMBL20865689 | 0.82 | RECQL (0.38) | CYP1A2CYP3A4MAPK1IDO1TSHR | |
| SCHEMBL257057 | 0.82 | DAO (0.48) | PDE2ATRPA1CYP1A2CYP2A6SIGMAR1 | |
| SCHEMBL26581124 | 0.82 | CSNK2A1 (0.47) | CYP3A4IDO1CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL12344072 | 0.80 | CYP2A6 (0.37) | PDE2ATRPA1CYP1A2CYP2A6SIGMAR1 | |
| SCHEMBL5144225 | 0.79 | ALDH1A1 (0.42) | CYP1A2SIGMAR1MAPK1TDP1SMN1; SMN2 | |
| SCHEMBL22243486 | 0.79 | PNMT (0.46) | SIGMAR1CYP2C9CSNK2A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240228484-A1 | MONOACYLGLYCEROL LIPASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2024-07-11 | — | — | US | disclosed |
| EP-3131897-B1 | FACTOR IXA INHIBITORS | MERCK SHARP & DOHME (US) | 2022-06-15 | — | — | EP | disclosed |
| US-10703747-B2 | Benzothiophene-based selective mixed estrogen receptor downregulators | The Board of Directors of the University of Illinois (US) | 2020-07-07 | — | — | US | disclosed |
| US-20190248780-A1 | BENZOTHIOPHENE-BASED SELECTIVE MIXED ESTROGEN RECEPTOR DOWNREGULATORS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLNOIS (US) | 2019-08-15 | — | — | US | disclosed |
| US-20120165320-A1 | NOVEL AZABICYCLOHEXANES | PANACEA BIOTEC LTD. (IN) | 2012-06-28 | — | — | US | disclosed |
| US-20120040951-A1 | HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | SUNESIS PHARMACEUTICALS, INC. | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190248780-A1 | BENZOTHIOPHENE-BASED SELECTIVE MIXED ESTROGEN RECEPTOR DOWNREGULATORS | ESR1, ESR2, GPER1 | PDE2A 4607/4885HSPA5 844/4885TRPA1 966/4885 |
| US-20240228484-A1 | MONOACYLGLYCEROL LIPASE MODULATORS | MGLL, LPL, PNLIP | PDE2A 724/4885HSPA5 4565/4885TRPA1 1605/4885 |
| US-20120040951-A1 | HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | BRAF, RAF1, ARAF | PDE2A 3354/4885HSPA5 2375/4885TRPA1 4786/4885 |
| US-20120165320-A1 | NOVEL AZABICYCLOHEXANES | CYP3A43, UGT1A1, CYP3A4 | PDE2A 767/4885HSPA5 4296/4885TRPA1 2412/4885 |
| US-10703747-B2 | Benzothiophene-based selective mixed estrogen receptor downregulators | ESR1, ESR2, GPER1 | PDE2A 4607/4885HSPA5 844/4885TRPA1 966/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.