Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4030047 | 0.83 | RAB9A (0.64) | TSHRHTTNPC1RAB9AAPEX1 | |
| SCHEMBL11801105 | 0.81 | MAPK1 (0.56) | TSHRHTTNPC1RAB9AAPEX1 | |
| SCHEMBL11135310 | 0.81 | TSHR (0.56) | TSHRHTTNPC1RAB9AAPEX1 | |
| SCHEMBL20540420 | 0.79 | MEN1 (0.61) | TSHRHTTNPC1RAB9AAPEX1 | |
| SCHEMBL7254129 | 0.78 | KCNMA1 (0.58) | TSHRHTTNPC1RAB9AMAPT | |
| SCHEMBL10810548 | 0.76 | TSHR (0.50) | TSHRHTTNPC1RAB9AAPEX1 | |
| SCHEMBL10813601 | 0.76 | ABL1 (0.50) | TSHRHTTNPC1RAB9AAPEX1 | |
| SCHEMBL10706727 | 0.76 | TSHR (0.50) | TSHRHTTNPC1RAB9AAPEX1 | |
| SCHEMBL1019310 | 0.76 | ALDH1A1 (0.50) | TSHRHTTNPC1RAB9AAPEX1 | |
| SCHEMBL8927627 | 0.75 | ALDH1A1 (0.49) | TSHRHTTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271624-A1 | IMINOPYRIDINE DERIVATIVES AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009131245-A1 | IMINOPYRIDINE DERIVATIVES AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-10-29 | — | — | WO | disclosed |