Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.34 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 2/20 | 0.31 |
| ▸ | GABRD | O14764 | 2/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.31 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.31 |
| ▸ | GABRE | P78334 | 2/20 | 0.31 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19704988 | 0.84 | CHRNB2 (0.53) | CHRNB2CHRNB4CHRNA4ALDH1A1PHF8 | |
| SCHEMBL620412 | 0.81 | CA1 (0.36) | ALDH1A1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL1191256 | 0.81 | ALDH1A1 (0.63) | CHRNB2CHRNB4CHRNA4ALDH1A1PHF8 | |
| SCHEMBL12888085 | 0.79 | ALDH1A1 (0.46) | CHRNB2CHRNB4CHRNA4ALDH1A1PHF8 | |
| SCHEMBL26700537 | 0.78 | MEN1 (0.35) | CHRNB2CHRNB4CHRNA4PHF8KDM2A | |
| SCHEMBL10161025 | 0.77 | CHRNB2 (0.40) | CHRNB2CHRNB4CHRNA4ALDH1A1 | |
| SCHEMBL16816192 | 0.76 | ALDH1A1 (0.52) | CHRNB2CHRNB4CHRNA4ALDH1A1PHF8 | |
| SCHEMBL28831888 | 0.73 | ALDH1A1 (0.37) | ALDH1A1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL1517765 | 0.72 | CHRNB2 (0.56) | CHRNB2CHRNB4CHRNA4ALDH1A1PHF8 | |
| SCHEMBL668762 | 0.72 | UBE2N (0.41) | CHRNB2CHRNB4CHRNA4PHF8KDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220177522-A1 | PROLINE-LOCKED STAPLED PEPTIDES AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2022-06-09 | — | — | US | disclosed |
| US-9617309-B2 | Proline-locked stapled peptides and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-04-11 | — | — | US | disclosed |
| US-20150239937-A1 | PROLINE-LOCKED STAPLED PEPTIDES AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-08-27 | — | — | US | disclosed |
| US-20120035194-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | PFIZER INC. (US) | 2012-02-09 | — | — | US | disclosed |
| US-7998978-B2 | Substituted 2-amino-fused heterocyclic compounds | PFIZER INC. (US) | 2011-08-16 | — | — | US | disclosed |
| US-7887835-B2 | for vascular lesion imaging and for diagnosing arteriosclerosis, ischemia with X-ray angiography and positron emission tomography; fluorinated steroid ester, glyceride compounds, phosphatidylcholine, and phosphatidylserine as membrane components of liposome | FUJIFILM CORPORATION (JP) | 2011-02-15 | — | — | US | disclosed |
| US-20100056506-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2010-03-04 | — | — | US | disclosed |
| US-20080138285-A1 | Compound comprising a fluorine-substituted alkyl group and a liposome contrast medium comprising the compound | FUJIFILM CORPORATION (JP) | 2008-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080138285-A1 | Compound comprising a fluorine-substituted alkyl group and a liposome contrast medium comprising the compound | PHOSPHO1, SGMS1, SGMS2 | CHRNB2 4790/4885CHRNB4 4585/4885CHRNA4 4734/4885 |
| US-20120035194-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | MAPK1, SLC5A1, ATF1 | CHRNB2 3160/4885CHRNB4 3267/4885CHRNA4 3551/4885 |
| US-20100056506-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | MAPK1, SLC5A1, ATF1 | CHRNB2 3160/4885CHRNB4 3267/4885CHRNA4 3551/4885 |
| US-20150239937-A1 | PROLINE-LOCKED STAPLED PEPTIDES AND USES THEREOF | PRAP1, PRR12, NPPA | CHRNB2 4710/4885CHRNB4 4722/4885CHRNA4 4798/4885 |
| US-20220177522-A1 | PROLINE-LOCKED STAPLED PEPTIDES AND USES THEREOF | PRAP1, PRR12, NPPA | CHRNB2 4710/4885CHRNB4 4722/4885CHRNA4 4798/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.