Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 14/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 7/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | BRD2 | P25440 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17897054 | 0.92 | BRD4 (0.46) | BRD4CREBBPCYP11B2CYP11B1 | |
| SCHEMBL17896762 | 0.82 | BRD4 (0.48) | BRD4CREBBPBRD2 | |
| SCHEMBL10175601 | 0.81 | HTR2B (0.43) | BRD4CREBBPCYP11B2CYP11B1 | |
| SCHEMBL10175348 | 0.81 | CYP11B2 (0.48) | CYP11B2CYP11B1 | |
| SCHEMBL10175342 | 0.78 | CYP11B2 (0.46) | CYP11B2CYP11B1 | |
| SCHEMBL17896641 | 0.78 | CYP11B2 (0.47) | CYP11B2CYP11B1 | |
| SCHEMBL17896739 | 0.77 | BRD4 (0.48) | BRD4CREBBPCYP11B2CYP11B1 | |
| SCHEMBL10175439 | 0.77 | CYP11B2 (0.46) | CYP11B2CYP11B1 | |
| SCHEMBL17896691 | 0.77 | BRD4 (0.44) | BRD4CREBBPCYP11B2CYP11B1 | |
| SCHEMBL17896642 | 0.77 | ALOX5AP (0.46) | CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |