Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 18/20 | 0.73 |
| ▸ | CYP11B1 | P15538 | 15/20 | 0.73 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17896681 | 0.85 | CYP11B2 (0.59) | CYP11B2CYP11B1CYP19A1ADRA2BUSP2 | |
| SCHEMBL10176165 | 0.84 | CYP11B2 (1.00) | CYP11B2CYP11B1USP2HTTNCOA1 | |
| SCHEMBL10175581 | 0.82 | CYP11B2 (0.71) | CYP11B2CYP11B1CYP19A1ADRA2BADRB1 | |
| SCHEMBL459787 | 0.75 | CYP11B2 (0.79) | CYP11B2CYP11B1CYP19A1ADRA2BADRB1 | |
| SCHEMBL10175616 | 0.74 | CYP11B1 (0.43) | CYP11B2CYP11B1CYP19A1ADRA2BUSP2 | |
| SCHEMBL17896718 | 0.73 | CYP11B2 (0.56) | CYP11B2CYP11B1CYP19A1ADRA2BADRB1 | |
| SCHEMBL10176203 | 0.72 | CYP11B2 (0.69) | CYP11B2CYP11B1CYP19A1ADRA2BADRB1 | |
| SCHEMBL1537646 | 0.72 | CYP11B1 (0.53) | CYP11B2CYP11B1HTR2C | |
| SCHEMBL3967675 | 0.72 | CYP11B1 (0.53) | CYP11B2CYP11B1HTR2C | |
| SCHEMBL17896597 | 0.71 | CYP11B2 (0.59) | CYP11B2CYP11B1CYP19A1ADRA2BADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |