Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 2/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.44 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 8/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10176252 | 0.90 | KDM4E (0.50) | FLT3KDM4EMAPTDAOHPGD | |
| SCHEMBL13814197 | 0.84 | NPC1 (0.54) | FLT3KDM4EMAPTDAOHPGD | |
| SCHEMBL10227643 | 0.83 | FLT3 (0.59) | FLT3SIRT2KDM4EMAPTDAO | |
| SCHEMBL10176353 | 0.80 | FLT3 (0.38) | FLT3KDM4EMAPTDAOHPGD | |
| SCHEMBL10176214 | 0.78 | NPC1 (0.53) | KDM4EMAPTHPGDALDH1A1ESR1 | |
| SCHEMBL5653870 | 0.77 | FLT3 (0.64) | FLT3KDM4EMAPTDAOHPGD | |
| SCHEMBL10176182 | 0.76 | FLT3 (0.54) | FLT3KDM4EMAPTHPGDHSD17B10 | |
| SCHEMBL10227650 | 0.72 | FLT3 (0.65) | FLT3KDM4EMAPTDAOHPGD | |
| SCHEMBL10227642 | 0.71 | FLT3 (0.54) | FLT3KDM4EMAPTDAOHPGD | |
| SCHEMBL10729949 | 0.70 | ALDH1A1 (0.50) | FLT3KDM4EHPGDHSD17B10PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120022121-A1 | INDOLES, DERIVATIVES AND ANALOGS THEREOF AND USES THEREFOR | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2012-01-26 | — | — | US | disclosed |
| US-20090142832-A1 | Indoles, Derivatives, and Analogs Thereof and Uses Therefor | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2009-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022121-A1 | INDOLES, DERIVATIVES AND ANALOGS THEREOF AND USES THEREFOR | TUBB, TUBB3, TUBB1 | FLT3 3889/4885HSD17B1 1263/4885HSD17B2 1589/4885 |
| US-20090142832-A1 | Indoles, Derivatives, and Analogs Thereof and Uses Therefor | TUBB, TUBB1, TUBB6 | FLT3 3133/4885HSD17B1 1671/4885HSD17B2 1932/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.