Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 6/20 | 0.59 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.56 |
| ▸ | CLK1 | P49759 | 1/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10227650 | 0.90 | FLT3 (0.65) | FLT3MAP2K1CLK1DYRK1APDGFRB | |
| SCHEMBL10227642 | 0.87 | FLT3 (0.54) | FLT3MAP2K1CLK1DYRK1APDGFRB | |
| SCHEMBL15558759 | 0.85 | FLT3 (0.71) | FLT3MAP2K1CLK1DYRK1APDGFRB | |
| SCHEMBL423127 | 0.84 | FLT3 (0.61) | FLT3MAP2K1CLK1DYRK1APDGFRB | |
| SCHEMBL10176247 | 0.83 | FLT3 (0.44) | FLT3MAP2K1PDGFRBPDGFRAEGFR | |
| SCHEMBL10176444 | 0.83 | FLT3 (0.55) | FLT3MAP2K1CLK1DYRK1APDGFRB | |
| SCHEMBL2729915 | 0.80 | FLT3 (0.79) | FLT3MAP2K1CLK1DYRK1APDGFRB | |
| SCHEMBL10227645 | 0.79 | ASH1L (0.55) | FLT3MAP2K1CLK1DYRK1APDGFRB | |
| SCHEMBL424534 | 0.79 | PDGFRB (0.59) | FLT3MAP2K1PDGFRBPDGFRAHDAC6 | |
| SCHEMBL18965053 | 0.79 | ATM (0.59) | CLK1DYRK1AMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120022121-A1 | INDOLES, DERIVATIVES AND ANALOGS THEREOF AND USES THEREFOR | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2012-01-26 | — | — | US | disclosed |
| US-20090142832-A1 | Indoles, Derivatives, and Analogs Thereof and Uses Therefor | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2009-06-04 | — | — | US | disclosed |
| WO-2009070645-A1 | INDOLES, DERIVATIVES, AND ANALOGS THEREOF AND USES THEREOF | THE OHIO UNIVERSITY RESEARCH FOUNDATION (US) | 2009-06-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022121-A1 | INDOLES, DERIVATIVES AND ANALOGS THEREOF AND USES THEREFOR | TUBB, TUBB3, TUBB1 | FLT3 3889/4885MAP2K1 1533/4885CLK1 2230/4885 |
| US-20090142832-A1 | Indoles, Derivatives, and Analogs Thereof and Uses Therefor | TUBB, TUBB1, TUBB6 | FLT3 3133/4885MAP2K1 2469/4885CLK1 2821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.