Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 4/20 | 0.40 |
| ▸ | CA2 | P00918 | 4/20 | 0.40 |
| ▸ | CA9 | Q16790 | 4/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.40 |
| ▸ | CA3 | P07451 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.39 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5681941 | 0.79 | TBXAS1 (0.55) | ALDH1A1KDM4ETBXAS1KMT2ANAMPT | |
| Hydrochloric Acid SCHEMBL8801622 | 0.78 | ALDH1A1 (0.51) | ALDH1A1KDM4ETBXAS1SMN1; SMN2LMNA | |
| SCHEMBL7804458 | 0.75 | PKM (0.53) | ALDH1A1KDM4ETBXAS1HSD17B10TSHR | |
| Hydrochloric Acid SCHEMBL9853948 | 0.73 | TAAR1 (0.62) | ALDH1A1KDM4ETBXAS1TSHRSMN1; SMN2 | |
| SCHEMBL4016565 | 0.71 | TBXAS1 (0.50) | TBXAS1SMN1; SMN2GAANAMPTTAAR1 | |
| SCHEMBL1018318 | 0.71 | CA2 (0.60) | ALDH1A1HSD17B10TSHRCA12CA2 | |
| SCHEMBL7869978 | 0.70 | HTT (0.62) | ALDH1A1KDM4EHSD17B10TSHRCA12 | |
| SCHEMBL1018690 | 0.70 | CA12 (0.57) | ALDH1A1HSD17B10TSHRCA12CA2 | |
| SCHEMBL2916604 | 0.70 | TSHR (0.56) | ALDH1A1HSD17B10TSHRCA12CA2 | |
| SCHEMBL1206780 | 0.70 | MEP1B (0.50) | ALDH1A1KDM4ETBXAS1HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271642-A2 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | Genentech, Inc. (US) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009126863-A2 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2009-10-15 | — | — | WO | disclosed |
| EP-1789390-A2 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | Genentech, Inc. (US) | 2007-05-30 | — | — | EP | disclosed |
| WO-2006028958-A2 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2006-03-16 | — | — | WO | disclosed |