Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TBXAS1 | P24557 | 5/20 | 0.47 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8685427 | 0.87 | GAA (0.56) | PKMALDH1A1KDM4EMAPK1L3MBTL1 | |
| SCHEMBL8690312 | 0.87 | HRH3 (0.58) | ALDH1A1L3MBTL1LMNAPOLB | |
| SCHEMBL8690703 | 0.85 | MAPT (0.60) | ALDH1A1KDM4EL3MBTL1LMNAHTT | |
| SCHEMBL8685265 | 0.82 | TDP1 (0.51) | ALDH1A1TBXAS1L3MBTL1LMNATDP1 | |
| SCHEMBL11581355 | 0.81 | TAAR1 (0.53) | ALDH1A1TSHRTBXAS1LMNA | |
| SCHEMBL8639331 | 0.79 | LTA4H (0.49) | — | |
| Hydrochloric Acid SCHEMBL8801622 | 0.79 | ALDH1A1 (0.51) | ALDH1A1KDM4ETBXAS1LMNACYP4F2 | |
| SCHEMBL6181232 | 0.78 | NPC1 (0.49) | ALDH1A1TSHRTBXAS1MEN1KMT2A | |
| SCHEMBL8684972 | 0.78 | FPR2 (0.43) | ALDH1A1KDM4EMAPK1LMNAKMT2A | |
| SCHEMBL8690250 | 0.78 | HRH3 (0.48) | ALDH1A1MAPK1TP53MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077931-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | AstraZeneca AB (SE) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059959-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 1999-11-25 | — | — | WO | disclosed |
| US-5081131-A | Omega-((hetero)alkyl)benz(cd)-indol-2-amines | AMERICAN CYANAMID COMPANY (US) | 1992-01-14 | — | — | US | disclosed |
| EP-0035863-B1 | IMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | Pfizer Limited (GB) | 1983-10-26 | — | — | EP | disclosed |