Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CTSC | P53634 | 1/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10183220 | 0.79 | CHRM2 (0.36) | OPRM1OPRK1OPRL1ADAM17ALDH1A1 | |
| SCHEMBL10184045 | 0.75 | OPRM1 (0.42) | OPRM1OPRK1OPRL1ALDH1A1GAA | |
| SCHEMBL10183828 | 0.74 | ALDH1A1 (0.42) | OPRM1OPRK1OPRL1ALDH1A1GAA | |
| SCHEMBL10185926 | 0.72 | OPRM1 (0.39) | OPRM1OPRK1OPRL1ALDH1A1GAA | |
| SCHEMBL10183666 | 0.72 | OPRM1 (0.39) | OPRM1OPRK1OPRL1ALDH1A1GAA | |
| SCHEMBL10185945 | 0.72 | OPRM1 (0.39) | OPRM1OPRK1OPRL1ADAM17ALDH1A1 | |
| SCHEMBL10184153 | 0.72 | OPRM1 (0.39) | OPRM1OPRK1OPRL1GAAHPGD | |
| SCHEMBL10183731 | 0.72 | USP2 (0.39) | OPRM1OPRK1OPRL1ALDH1A1HPGD | |
| SCHEMBL10183670 | 0.72 | TRPM8 (0.41) | OPRM1OPRK1OPRL1GAANPSR1 | |
| SCHEMBL10185867 | 0.72 | CCKBR (0.36) | OPRM1OPRK1OPRL1ADAM17ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009678-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |