Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 2/20 | 0.35 |
| ▸ | PNMT | P11086 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL667234 | 0.83 | NR3C1 (0.43) | LMNAKCNH2TMEM97POLBMEN1 | |
| SCHEMBL10186666 | 0.81 | SLC6A4 (0.51) | KCNH2CNR1CNR2SIGMAR1PNMT | |
| SCHEMBL10186685 | 0.81 | HTR1A (0.42) | POLBMEN1KMT2ACNR1CNR2 | |
| SCHEMBL7637395 | 0.79 | CNR1 (0.45) | MEN1KMT2ACNR1CNR2SIGMAR1 | |
| SCHEMBL14438275 | 0.78 | MEN1 (0.43) | LMNAKCNH2POLBMEN1KMT2A | |
| SCHEMBL10186681 | 0.76 | POLB (0.45) | POLBMEN1KMT2AGAA | |
| SCHEMBL10186620 | 0.75 | POLB (0.41) | KCNH2POLBMEN1KMT2ASIGMAR1 | |
| SCHEMBL16870109 | 0.75 | SIGMAR1 (0.45) | KCNH2TMEM97KMT2ASIGMAR1ACACB | |
| SCHEMBL15979353 | 0.75 | KCNH2 (0.43) | LMNAKCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL321307 | 0.74 | CNR1 (0.46) | POLBCNR1CNR2SIGMAR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | LMNA 1559/4885KCNH2 1215/4885TMEM97 4129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.