Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.42 |
| ▸ | HTR1D | P28221 | 3/20 | 0.42 |
| ▸ | HTR1B | P28222 | 3/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | HTR7 | P34969 | 3/20 | 0.42 |
| ▸ | HTR2B | P41595 | 3/20 | 0.42 |
| ▸ | HTR5A | P47898 | 3/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | HTR1E | P28566 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10186666 | 0.86 | SLC6A4 (0.51) | HTR1AHTR1DHTR1BHTR2AHTR7 | |
| SCHEMBL8251205 | 0.85 | HTR1A (0.44) | HTR1AHTR1DHTR1BHTR2AHTR7 | |
| SCHEMBL10186682 | 0.84 | SIGMAR1 (0.36) | HTR1AHTR1DHTR1BHTR2AHTR7 | |
| SCHEMBL10186664 | 0.83 | MEN1 (0.55) | SIGMAR1MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL7637395 | 0.83 | CNR1 (0.45) | CNR1CNR2SIGMAR1MEN1KMT2A | |
| SCHEMBL10186676 | 0.81 | LMNA (0.39) | CNR1CNR2SIGMAR1MEN1KMT2A | |
| SCHEMBL10186673 | 0.81 | MEN1 (0.49) | SIGMAR1MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL18685158 | 0.79 | BCHE (0.48) | HTR1AHTR1DHTR1BHTR2AHTR7 | |
| SCHEMBL10186620 | 0.79 | POLB (0.41) | SIGMAR1MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL321307 | 0.78 | CNR1 (0.46) | CNR1CNR2SIGMAR1GAAPNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | HTR1A 3776/4885HTR1D 3918/4885HTR1B 3055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.